脆弱性评估:老年人与艾滋病毒感染者 (PLHIV) 的新兴概念
Adhya Mehta1, Sohini Halder1, Sanjay Pandit1
1Department of Medicine, Maulana Azad Medical College and Associated Lok Nayak Hospital, New Delhi, Delhi, India.
Journal of family medicine and primary care
|February 16, 2024
概括
在印度,艾滋病毒感染的老年人中,虚弱是常见的,影响了超过一半的研究对象. 低CD4计数和多种健康问题是关键预测因素,突出强调需要超越传统指标的综合护理.
科学领域:
- 老年学是指老年学的学科.
- 传染性疾病 传染性疾病
- 临床医学 临床医学
背景情况:
- 抗逆转录病毒治疗 (ART) 改善了艾滋病毒感染者 (PLHIV) 的预期寿命.
- 现在,PLHIV面临着加速衰老和相关疾病,如虚弱,影响高达28%.
- 脆弱性是不利结果的预测因素,但在印度仍未得到充分研究.
研究的目的:
- 探索印度PLHIV人群中脆弱性的流行情况.
- 为了确定与这一群体的脆弱性相关的决定因素.
主要方法:
- 对76名年龄在50岁及以上的PLHIV进行横截面研究.
- 使用弗里德标准和退伍军人衰老队列研究 (VACS) 指数评估的脆弱性.
- 对社会人口统计学,临床,免疫学和病毒学因素的分析.
主要成果:
- 超过一半 (57.89%) 的PLHIV被确定为易受伤害或易受伤害.
- 显著与低CD4计数 (P=0.0001) 和多药性 (P=0.033) 相关的脆弱性.
- 低CD4细胞计数 (≤200细胞/毫米3) 是脆弱性的最强的独立预测因素.
结论:
- 在印度的老年PLHIV中观察到的虚弱和营养不良的高患病率.
- 强调需要对PLHIV护理采取整体方法,考虑到脆弱性和老龄化.
- 建议将重点从传统的终点转移到全面的结果测量.
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