在第三级护理医院接种疫苗之前和之后入院的患者中,对COVID-19疾病严重程度和结果进行了比较研究
Narayan Mood1, Surendra Babu Darivemula2, Sreeram Shravani3
1Associate Professor, Department of Respiratory Medicine, ESIC Medical College, Sanath Nagar, Hyderabad, Telangana, India.
Journal of family medicine and primary care
|February 16, 2024
概括
接种疫苗显著降低了COVID-19的严重程度,并改善了结果. 与未接种疫苗的人相比,接种至少一剂疫苗的患者患病的严重程度较低,这凸显了COVID-19疫苗接种的重要性.
科学领域:
- 传染性疾病 传染性疾病
- 疫苗学 疫苗学 疫苗学
- 公共卫生 公共卫生
背景情况:
- 冠状病毒疾病2019 (COVID-19),由SARS-CoV-2引起,导致全球卫生危机,严重病例的死亡率高.
- COVID-19疫苗的出现促使人们对其对疾病严重程度和患者结果的影响进行调查.
研究的目的:
- 评估和比较COVID-19在接种疫苗之前和之后入院的患者的严重程度和结果.
- 确定疫苗接种状态对危急疾病指标和患者预后的影响.
主要方法:
- 一项前性观察性研究包括172名成年患者呈SARS-CoV-2阳性.
- 患者根据疫苗接种情况进行分类:接种前,至少一剂量或两剂量.
- 使用高分辨率计算机断层扫描 (HRCT) 评分,ICU入院,氧和 (SpO2),机械通风和其他临床参数来评估疾病的严重程度.
主要成果:
- 在172名参与者中,92人感染了疫苗接种前,80人感染了疫苗接种后. 在未接种疫苗的组 (45.7%) 与接种疫苗的组 (17.5%) (P<0.001) 相比,ICU入院率显著高.
- 严重疾病的指标,包括低SpO2,需要高流量氧气,血交换,类固醇和机械通风,与疫苗接种状态有显著的关联 (P<0.05).
结论:
- 未接种疫苗的患者经历了更严重的COVID-19和更糟糕的结果.
- 接收至少一剂COVID-19疫苗与明显减少疾病严重程度和更好的预后有关.
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