COVID-19与加密球菌病相关:一个范围审查
Alvaro Quincho-Lopez1, Nuvith Poma2, Juan José Montenegro-Idrogo3,4,5
1Unidad de Investigación en Bibliometría, Vicerrectorado de Investigación, Universidad San Ignacio de Loyola, Lima, Peru.
Therapeutic advances in infectious disease
|February 16, 2024
概括
在COVID-19患者中,可能会出现严重的真菌感染 - - 密码球菌病. 这次审查发现,男性性别,年龄较大和ICU入院等因素与这些病例的死亡率较高有关.
科学领域:
- 传染性疾病 传染性疾病
- 关键护理医学 关键护理医学
- 菌类学 菌类学是指菌类学.
背景情况:
- 包括加密球菌病在内的真菌感染在COVID-19患者中越来越多地被发现.
- 虽然比其他真菌共感染不太常见,但COVID-19患者的加密球菌病可能严重且危及生命.
研究的目的:
- 识别和分析与COVID-19同时发生的加密菌病例.
- 为了比较幸存者和非幸存者之间的特征和管理策略.
主要方法:
- 对多个数据库 (PubMed,Scopus,Web of Science,Embase) 进行了全面的范围审查.
- 包括的研究包括案例报告,案例系列和原始文章,没有语言限制.
- 数据提取的重点是患者人口统计,COVID-19的严重程度,加密球菌病的呈现和结果.
主要成果:
- 对65个个别病例的分析显示,大多数患者是男性 (73.9%),平均年龄为60岁.
- 严重的COVID-19,并发症 (高血压,糖尿病),重症监护室 (ICU) 的入院和机械通风 (MV) 是常见的.
- 在55.4%的患者中发生了传播性密码球菌病,总死亡率为47.7%.
结论:
- 密码球菌病是COVID-19患者的一个新兴问题,尽管不像其他真菌感染那样普遍.
- 与死亡率相关的因素包括男性性别,晚年,ICU入院,MV,二次感染和淋巴衰竭.
- 很少有患有密码球菌病的COVID-19患者出现了经典的免疫抑制,突出了需要更广泛的临床怀疑的需要.
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