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描述和对Ajuugarin I和Ajuga bracteosa的伤口愈合潜力的比较评估 Wall. 之前的BenthBenth是什么意思

Yusra Wasti¹, Durdana Muntaqua², Muhammad Majid³

¹Department of Pharmacy, Faculty of Biological Sciences, Quaid-i-Azam University, Islamabad, Pakistan.

Frontiers in chemistry

|February 16, 2024

概括

青甲骨干提取物及其化合物阿加林I显示出显著的抗氧化,抗菌和伤口愈合特性. 植物提取物在所有测试试验中都表现出卓越的疗效,表明其作为治疗伤口愈合的治疗剂的潜力.

科学领域:

药理学药理学是指药理学的学科.
民族医学民族医学
自然产品化学自然产品化学

背景情况:

青 (Ajuga bracteosa) 是一种来自拉米叶科 (Lamiaceae) 家族的民族药用植物.
传统用途表明潜在的治疗应用,需要科学验证.

研究的目的:

为了比较Ajuga bracteosa提取物及其分离化合物Ajuugarin I的体外抗氧化和抗菌活性,请参阅.
评估和比较Ajuga bracteosa提取物和Ajugarin I.的体内伤口愈合潜力.

主要方法:

逆相高性能液态染色学 (RP-HPLC) 用于量化阿加林I和多.
在体外抗氧化剂测定:铁减少抗氧化能力 (FRAP),总抗氧化能力 (TAC) 和自由基清除.
在体外抗菌试验 (MIC确定),毒性试验 (溶血和皮肤),以及在小鼠体内切除伤口模型.

主要成果:

与Ajuugarin I相比,Ajuga bracteosa提取物表现出明显更高的抗氧化活性 (1.86-3.15倍).
植物提取物显示了比Ajugarin I (2/5菌株) 更广泛的抗菌谱 (3/5菌株).
艾古加布拉克托萨表现出优越的伤口愈合 (100%的收缩,9.33天的表皮质化) 与艾古加林I (95.6%的收缩,11.6天的表皮质化) 相比,具有有利的组织病理发现.

结论:

青木草提取物具有强大的抗氧化,抗菌和伤口愈合特性,性能优于单独的Ajuugarin I.
提取物和Ajugarin I都是无毒的,是开发新创伤愈合疗法的有希望的候选人.

关键词:

一个名为Ajuga的物种.在阿朱加林,我高压液体色谱学高压液体色谱学聚醇是一种多醇.伤口愈合伤口愈合

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