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大豆面包对心血管风险因子,炎症和氧化应激的作用,在患有活性类风湿性关节炎的妇女中:一项随机双盲对照试验

Afsaneh Sayyaf¹, Ehsan Ghaedi², Fatemeh Haidari³

¹Department of Nutritional Sciences, Faculty of Paramedical, Ahvaz Jundishapur University of Medical Sciences, Ahvaz 6135715753, Iran.

Clinical nutrition research

|February 16, 2024

概括

在类风湿性关节炎 (RA) 患者中,大豆面包的消费显著降低了瘤亡因子-α (TNF-α). 然而,其他炎症标志物和脂质样本没有显著变化,表明大豆在RA中具有特定的抗炎作用.

科学领域:

免疫学免疫学免疫学
营养科学营养科学
类风湿病学类风湿病学

背景情况:

类风湿性关节炎 (RA) 是一种全身性炎症性自身免疫性疾病.
大豆异黄具有已知的抗炎性质.
之前在动物模型上进行的研究表明,大豆补充对RA有好处.

研究的目的:

评估大豆面包对RA患者炎症标志物的影响.
为了评估RA患者食用大豆面包脂质谱的变化.
调查大豆面包对疾病活性得分的影响 (DAS28).

主要方法:

这是一项随机对照试验,涉及44名RA患者.
参与者被分配在8周内食用大豆面包或安慰剂面包.
测量了血清中的脂质谱,总抗氧化能力 (TAC),瘤缩因子-α (TNF-α),C反应蛋白 (CRP) 和DAS28.

主要成果:

与安慰剂相比,食用大豆面包导致血清TNF-α水平显著降低.
在大豆面包和安慰剂组之间,没有观察到脂质谱,TAC,CRP或DAS28的显著差异.
在整个研究期间,饮食摄入量和体育活动在各组之间保持一致.

结论:

在RA患者中,大豆面包补充剂特别降低了循环TNF-α.
该研究没有发现大豆面包对其他测量的炎症标志物或脂质配置文件有显著影响.
需要进一步的长期研究来证实大豆在RA中的这些特殊抗炎作用.

关键词:

关节炎,类风湿性关节炎功能性食品是一种功能性食品.炎症炎症是一种炎症.氧化应激是一种氧化应激.随机对照试验是随机对照试验.豆类食品豆类食品豆类食品

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