芬太尼尔皮肤贴片合理临床使用指南
1Department of Oncology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, 430030, People's Republic of China.
Drug design, development and therapy
|February 16, 2024
概括
癌症疼痛管理在中国面临的挑战与非理性的止痛药使用. 跨皮芬太尼贴片的新指导方针旨在改善合理的药物应用和患者护理.
科学领域:
- 在瘤学瘤学.
- 抚慰性护理是一种缓解性护理.
- 药理学 药理学是指药理学的学科.
背景情况:
- 癌症疼痛显著影响患者的生活质量,并造成巨大的经济负担.
- 不合理使用止痛药,包括穿皮芬太尼贴片,是中国癌症疼痛管理的一个重大挑战.
- 医疗保健专业人员对芬太尼通过皮肤贴片特征的理解不足,阻碍了适当的临床应用.
研究的目的:
- 为应对中国癌症疼痛管理的挑战.
- 制定和推广用于 fentanyl 通过皮肤贴片的临床使用的标准化指南.
- 提高癌症疼痛治疗的护理质量和安全性.
主要方法:
- 湖北抗癌协会癌症康复和息治疗专业委员会发起并编制了"芬太尼尔皮肤贴片合理临床使用指南".
- 多学科专家组 (医学,药房,护理) 参与指南制定,包括概述,准备和修订法规.
- 所有专家严格审查和最终确定过程,以确保准确性和科学有效性.
主要成果:
- 为湖北省量身定制的全面的"芬太尼跨皮贴片合理临床使用指南".
- 专家通过反复修订和科学真实性检查达成共识.
- 一个最终的指南,以支持合理的药物使用和管理.
结论:
- 制定的指导方针对于促进在中国合理临床使用芬太尼跨皮贴片至关重要.
- 预计这些指导方针的实施将减少癌症患者及其家人的心理和经济负担.
- 这些指导方针旨在提高医疗质量,确保癌症疼痛管理中的患者安全.
相关概念视频
01:22Drug Delivery: Miscellaneous Routes
339
Drug delivery methods like oral inhalation, nasal sprays, transdermal patches, eye drops, intravitreal injection, and rectal administration provide localized effects with reduced toxicity.
Oral inhalation and nasal sprays swiftly transfer drugs across the respiratory epithelium's mucosal layer. Inhaled glucocorticoids and bronchodilators directly target lung conditions such as asthma, while fluticasone nasal spray mitigates allergic rhinitis.
Transdermal patches transport drugs...
Oral inhalation and nasal sprays swiftly transfer drugs across the respiratory epithelium's mucosal layer. Inhaled glucocorticoids and bronchodilators directly target lung conditions such as asthma, while fluticasone nasal spray mitigates allergic rhinitis.
Transdermal patches transport drugs...
339
01:15Opioid Analgesics: Synthetic and Semisynthetic Opioids
299
Synthetic and semisynthetic opioids are pivotal in pain management and tackling opioid addiction. Semisynthetic opioids, including morphinans (morphine derivatives), oxycodone, oxymorphone, hydrocodone, and hydromorphone, have improved pharmacokinetic profiles compared to morphine. Additionally, heroin and 6-MAM (6-Monoacetylmorphine) show better CNS penetration than morphine due to heightened lipid solubility. Hydromorphone, a potent opioid, undergoes hepatic metabolism to form the active...
299
01:25Analgesia and Pain Management
623
Pain is critical to various clinical pathologies, provoking an urgent need for effective management. Pain, whether acute or chronic, is a complex neurochemical process. Its alleviation depends on the type, with nonopioid analgesics effective for mild to moderate pain, such as musculoskeletal or inflammatory pain, while neuropathic pain responds best to anticonvulsants, tricyclic antidepressants, or serotonin/norepinephrine reuptake inhibitors. For severe acute or chronic pain, opioids may be...
623
01:24Rational Dosage Regimen: Maintenance Dose and Loading Dose
4.1K
A rational dosage regimen considers a drug's pharmacokinetics, including its absorption, distribution, metabolism, and elimination from the body. By understanding these factors, the appropriate dosage can be determined, and the dosing schedule can be designed to achieve and maintain the desired therapeutic effect while minimizing adverse effects.
In most cases, drugs are administered repetitively or infused continuously to maintain a steady-state concentration in the body. At a steady...
In most cases, drugs are administered repetitively or infused continuously to maintain a steady-state concentration in the body. At a steady...
4.1K
01:20Opioid Analgesics: Morphine and Other Natural Cogeners
250
Opioids are a class of drugs that mimic endogenous opioid peptides and act on opioid receptors, and help in pain relief. These compounds are classified as natural, synthetic, or semi-synthetic. Natural opioids, like morphine, codeine, and thebaine, are derived from the opium poppy plant (Papaver somniferum or Papaver album) and are termed opiates. Synthetic opioids are artificial, while semi-synthetic opioids combine natural and synthetic compounds. Morphine, a prototypical opioid, possesses a...
250
01:18Additional Routes of Drug Administration
2.8K
Choosing the appropriate route of drug administration is significantly influenced by two key factors: the therapeutic objectives and the inherent properties of the drug being used.
Administering drugs via inhalation allows for the direct delivery of gaseous, volatile substances or droplets to different parts of the respiratory tract. One of the advantages of the inhalation route is the rapid absorption of drugs into the circulatory system, which is possible because of the large surface area of...
Administering drugs via inhalation allows for the direct delivery of gaseous, volatile substances or droplets to different parts of the respiratory tract. One of the advantages of the inhalation route is the rapid absorption of drugs into the circulatory system, which is possible because of the large surface area of...
2.8K