咖啡和骨关节炎的风险:一个两样本,两步多变量门德尔随机化研究
Wenzheng Zhang1, Xuefeng Lei1, Yihui Tu1
1Department of Orthopaedics, Yangpu Hospital, School of Medicine, Tongji University, Shanghai, China.
Frontiers in genetics
|February 16, 2024
概括
咖啡消费可能会增加骨关节炎的风险,尤其是膝关节骨关节炎. 体重指数 (BMI) 在很大程度上调解了这种风险,而无咖啡因咖啡显示出与骨关节炎发展的最强相关性.
科学领域:
- 流行病学 流行病学
- 遗传学 是一个遗传学.
- 营养科学 营养科学
背景情况:
- 骨关节炎 (OA) 是一种普遍存在的退行性关节疾病.
- 饮食因素 (如咖啡消费) 与OA风险之间的关系需要进一步阐明.
- 在这种关联中,身体质量指数 (BMI) 和骨矿物质密度 (BMD) 的潜在中介作用尚未完全理解.
研究的目的:
- 调查咖啡消费与骨关节炎 (OA) 之间的潜在因果关系.
- 确定身体质量指数 (BMI) 和骨矿物质密度 (BMD) 是否调解咖啡摄入量和OA之间的关系.
- 探索不同咖啡种类对OA风险的影响.
主要方法:
- 进行了两种样本和两步门德尔随机化 (MR) 分析.
- 用全基因组关联研究 (GWAS) 的总结统计数据来评估咖啡摄入量和OA风险.
- 分析考虑了不同的OA亚型 (膝盖,部,总体) 和各种咖啡类型 (无咖啡因,速溶咖啡,磨砂咖啡).
主要成果:
- 咖啡摄入量与多个部位关节炎的风险增加有关,最显著的是膝盖关节炎 (OR 2.03).
- 没有咖啡因的咖啡显示出与膝盖骨关节炎 (OR 4.40) 和自我报告的骨关节炎 (OR 1.13) 显著的因果关系.
- 身体质量指数 (BMI) 介导了超过50%的咖啡和OA风险关联,而骨矿物质密度 (BMD) 起到了很小的作用 (<5%).
结论:
- 咖啡消费似乎增加了患骨关节炎的风险.
- 身体质量指数 (BMI) 是咖啡与OA关系中的一个重要的调解因素.
- 由于其与OA风险的显著关联,消费无咖啡因咖啡值得注意;管理BMI对于咖啡饮用者至关重要.
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