活性维生素D类别对老年人肌肉强度和摔倒的影响:最新的元分析
An Xiong1, Haibo Li1, Miaoying Lin1
1National Clinical Research Center for Metabolic Diseases, Hunan Provincial Key Laboratory of Metabolic Bone Diseases, and Department of Metabolism and Endocrinology, The Second Xiangya Hospital of Central South University, Changsha, Hunan, China.
Frontiers in endocrinology
|February 16, 2024
概括
活性维生素D类似物在老年人中降低了19%的跌倒风险. 虽然它们没有改善整体肌肉力量,但它们显著增强四头肌力量,为与年龄相关的肌肉衰退提供了潜在的干预措施.
科学领域:
- 老年学是一门学科.
- 药理学 药理学是指药理学的学科.
- 临床营养学 临床营养学
背景情况:
- 老年人面临着因肌肉力量减弱而导致跌倒的高风险.
- 目前,没有任何药物被官方批准用于治疗与年龄相关的肌肉衰弱.
- 活性维生素D类型呈现出潜在的治疗途径,尽管之前的研究产生了不一致的结果.
研究的目的:
- 进行一项元分析,评估活性维生素D类别在提高肌肉力量和减少老年人群中跌倒的疗效.
主要方法:
- 在PubMed和Cochrane图书馆进行了系统的文献搜索,直到2023年8月.
- 来自随机对照试验 (RCT) 的数据使用风险比率 (RR) 和标准化平均差异 (SMD) 以95%置信区间 (95% CI) 进行分析.
- 分析包括对酸,阿尔法酸和埃尔德酸的研究,评估它们对肌肉力量和跌倒发生率的影响.
主要成果:
- 对三种活性维生素D类型的综合分析表明,跌倒风险降低了19%.
- 在综合或单独的分析中,没有观察到总体肌肉,手握或背部伸展器强度的显著改善.
- 在综合分析中,特别是在阿尔法卡尔西多尔和埃尔德卡尔西托尔方面,人们注意到四头肌强度的显著提高.
结论:
- 在老年人中,活性维生素D类型并不能增强整体,手握或背部延伸器的强度.
- 这些类似物有效地提高四头肌强度,并降低老龄化人口中跌倒的风险.
- 在分析的研究中,补充并没有改变维生素D对肌肉力量的影响.
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