沙雷类LAR对壮症的疗效:长期实践的单心研究
Vittoria Favero1,2, Benedetta Zampetti2, Emanuela I Carioni2
1Department of Biotechnology and Translational Medicine, University of Milan, Milan, Italy.
Frontiers in endocrinology
|February 16, 2024
概括
帕西雷奥提德-LAR (Pas-LAR) 有效治疗巨,在第一剂后可以早期识别反应. 这种长效治疗在对其他疗法的耐药性患者中显示出有效性和安全性.
科学领域:
- 内分泌学 在内分泌学.
- 药理学 药理学是指药理学的学科.
背景情况:
- 巨症是由于生长激素 (GH) 和类似胰岛素的生长因子1 (IGF1) 的过量导致的.
- 医疗治疗对于术后持续的壮症或当手术不可行时至关重要.
- 帕西雷奥提德-LAR (Pas-LAR) 是一种推的二线医疗治疗巨症.
研究的目的:
- 为了确定患者的特征,预测对帕西里奥提德-LAR (Pas-LAR) 的积极反应.
- 评估Pas-LAR在壮病患者的长期疗效和安全性.
- 评估对Pas-LAR治疗反应的早期指标.
主要方法:
- 从19名对一线治疗有抗性或不耐受性壮病患者的回顾性数据收集.
- 在Pas-LAR响应者 (n=14) 和非响应者 (n=5) 之间的基线特征的比较.
- 在响应患者中对Pas-LAR疗效和安全性的长期评估.
主要成果:
- 71.4%的响应者在一次Pas-LAR注射后实现了胰岛素类生长因子1 (IGF1) 的正常化.
- 与多个时间点的响应者相比,在不响应者中观察到更高的IGF1基线水平.
- 在第一个注射后,5/6个响应者中症状性头痛消失或改善;在6/7个评估响应者中发生瘤缩.
结论:
- 帕西雷奥提德-LAR (Pas-LAR) 证明了在治疗巨时的有效性和安全性.
- 早期识别Pas-LAR响应者是可行的,在最初的管理后.
- 帕斯-LAR为患有持续性或不可手术的壮症的患者提供了一种有价值的治疗选择.
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