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费里丁/淋巴细胞百分比比用于预测COVID-19的严重程度和死亡率

Nur Simsek Yurt¹, Metin Ocak²

¹Clinic of Family Medicine, Samsun Training and Research Hospital, Samsun, Turkey.

Malawi medical journal : the journal of Medical Association of Malawi

|February 16, 2024

概括

费里/淋巴细胞百分比 (FLPR) 是 COVID-19 严重性和死亡率的强有力的预测指标. 较高的FLPR水平与较差的临床结果和放射学发现相关,在死亡率预测中表现优于其他生物标志物.

科学领域:

传染性疾病传染性疾病
生物标志物生物标志物
临界护理医学临界护理医学

背景情况:

COVID-19 给全球健康带来了重大挑战,疾病的严重程度和死亡率在患者之间存在很大差异.
确定可靠的生物标志物来预测COVID-19的结果对于有效的患者管理和资源分配至关重要.

研究的目的:

调查费里/淋巴细胞百分比 (FLPR) 与COVID-19患者的临床/放射性疾病严重程度之间的关联.
评估FLPR在COVID-19中30天死亡率的预测值.

主要方法:

对309名PCR确诊感染的COVID-19患者进行了回顾性研究.
在紧急入院时从实验室测试中计算FLPR.
与胸部CT得分,疾病严重程度分级和30天死亡率的相关性分析.

主要成果:

FLPR与临床疾病严重程度有显著的相关性 (p <0.001),在危急和严重病例中更高.
在FLPR和胸部CT得分之间观察到显著的正相关性 (r=0.496,p<0.001).
与其他生物标志物相比,FLPR显示出30天死亡率 (AUC=0.924) 的优异预测值,最佳切断值为42.4 (灵敏度84.2%,特异性86.7%).

结论:

FLPR作为评估COVID-19疾病严重程度的独立生物标志物.
FLPR是COVID-19患者死亡率的有价值和强有力的预测指标.
这些发现支持FLPR在治疗COVID-19患者中的临床实用性.

关键词:

在 COVID-19 疫情中,疾病的严重程度.费里丁/淋巴细胞百分比比率.这是一种炎症炎症炎症炎症.死亡率死亡率预测价值是一个预测值.

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