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在COVID-19疫苗接种后,急性间歇性炎与急性损伤:一个病例报告
Jimin Lim1, Jin Hyuk Paek1,2, Hyeong Chan Shin3
1Division of Nephrology, Department of Internal Medicine, Keimyung University School of Medicine, Daegu, Korea.
Clinical and experimental vaccine research
|February 16, 2024
概括
一名年轻男子在瑞-生物科技COVID-19疫苗接种后出现了急性间歇性炎和损伤. 用普雷迪尼索隆治疗改善了他的功能,这表明了潜在的疫苗相关不良事件.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 免疫学 免疫学 免疫学
- 疫苗学 疫苗学 疫苗学
背景情况:
- 瑞-生物科技COVID-19疫苗的广泛使用需要对潜在的不良事件进行监测.
- 急性间歇性炎 (AIN) 是一种炎症性病,可能导致急性损伤 (AKI).
研究的目的:
- 在接种COVID-19疫苗后,在年轻人中报告AIN与AKI的病例.
- 为了突出COVID-19疫苗接种和AIN之间的潜在关联.
主要方法:
- 一个病例报告,一名20岁的男性在接种疫苗后出现了功能障碍的症状.
- 进行脏活检以评估脏病理.
- 用高剂量的普雷迪尼索隆进行治疗.
主要成果:
- 患者在接种瑞-生物科技疫苗9天后出现功能下降 (血清肌素1.8毫克/分升).
- 脏活检显示有淋巴细胞的扩散性间歇性炎症.
- 普雷尼索隆治疗导致功能逐渐改善.
结论:
- 接种COVID-19疫苗,特别是Pfizer-BioNTech疫苗,可能与急性间歇性炎有关.
- 临床医生应考虑在COVID-19疫苗接种后出现功能障碍的患者中进行AIN,尽管这种事件很少发生.
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