不对称的成长限制了女性概念的发展
Consuelo Amor S Estrella1,2, Kathryn L Gatford1,3, Ruidong Xiang1,2
1Robinson Research Institute, The University of Adelaide, Adelaide, SA, Australia.
Frontiers in endocrinology
|February 16, 2024
概括
女胎儿的产前生长和器官发育比男性慢,具有独特的胎盘和血管系统,优先考虑大脑和心脏的生长. 这可能会增强子宫内的性,并影响产后健康结果.
科学领域:
- 胎盘和胎儿发育的比较.
- 生殖生物学和内分泌学.
- 发展规划和疾病易感性
背景情况:
- 产前生长模式可以影响产后健康和疾病风险.
- 跨物种观察到胎儿发育中的性别差异.
- 了解早期生活编程对于长期健康结果至关重要.
研究的目的:
- 为了研究在妊娠中期牛胎发育的性别差异.
- 整合多omics和表型数据,以了解性别特定的生长模式.
- 探索女性胎儿生长限制和器官节约背后的机制.
主要方法:
- 综合表型,组织形态学,临床化学,内分泌和牛概念中的基因表达分析.
- 在怀孕中期对男性和女性胎儿和胎盘进行比较分析.
- 评估器官重量,身体组成,血管参数和关键基因表达 (IGF2).
主要成果:
- 与男性相比,女性胎儿的体重,体重指数和器官重量都较低.
- 女人显示较高的大脑:体重和心脏:体重比率,表明大脑和心脏节省.
- 女人的胎血管系统似乎限制了生长,有证据表明营养物质重新分配和改变了IGF2表达.
结论:
- 雌性牛的概念体在妊娠中期表现出特定于性别的,限制生长的表型,优先考虑大脑和心脏发育.
- 这种发展战略可能会赋予人与生俱来的环境挑战的弹性.
- 性别偏差的发育编程可能会影响生命后期对非传染性疾病的易感性.
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