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相关概念视频

Special Features of Adaptive Immunity01:20

Special Features of Adaptive Immunity

The adaptive immune system, a crucial component of the overall immune response, offers a highly specialized defense against pathogens. It involves specific cell types and features, enabling it to combat infections effectively and efficiently.
The primary cell types involved in adaptive immunity are T cells and B cells. Each type has a unique role in defending the body against pathogens. T cells are responsible for cell-mediated immunity. They identify and eliminate infected cells directly,...

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Correction to "[NSUN2 promotes colorectal cancer progression and increases lapatinib sensitivity by enhancing CUL4B/ErbB-STAT3 signalling in a non-m5C manner]".

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相关实验视频

Updated: Jun 7, 2026

The Use of the Ex Vivo Chandler Loop Apparatus to Assess the Biocompatibility of Modified Polymeric Blood Conduits
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Published on: August 20, 2014

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耐受CD47的人

Jeffrey S Isenberg1, Enrique Montero2

  • 1Department of Diabetes Complications & Metabolism, Arthur Riggs Diabetes & Metabolism Research Institute, City of Hope National Medical Center, Duarte, California, USA.

Clinical and translational medicine
|February 16, 2024
PubMed
概括
此摘要是机器生成的。

分化47集群 (CD47) 是一种细胞表面蛋白质,在细胞相互作用中具有复杂的作用. 了解它的双重功能是开发癌症和自身免疫性疾病新疗法的关键.

关键词:
CD47 CD47 CD47 CD47 CD47 CD47 CD47 CD47 CD47 CD47 CD47 CD47这就是SIRPα.在 TSP1 中使用 TSP1.这是自身免疫力.癌症 癌症 癌症 癌症 癌症检查点抑制剂的检查点抑制剂免疫疗法 免疫疗法

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A Real-time Potency Assay for Chimeric Antigen Receptor T Cells Targeting Solid and Hematological Cancer Cells
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Mitigation of Blood Borne Cell Attachment to Metal Implants through CD47-Derived Peptide Immobilization
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相关实验视频

Last Updated: Jun 7, 2026

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Mitigation of Blood Borne Cell Attachment to Metal Implants through CD47-Derived Peptide Immobilization
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科学领域:

  • 免疫学 免疫学 免疫学
  • 细胞生物学 细胞生物学
  • 药物开发 药物开发

背景情况:

  • 分化47集群 (CD47) 是一种细胞表面蛋白质,参与细胞与细胞的相互作用.
  • CD47在免疫反应中起作用,是药物开发的目标.
  • 之前对CD47阻断抗体的临床试验遭遇了挫折.

研究的目的:

  • 探索CD47.7.的复杂和看似相互矛盾的作用.
  • 为了研究调节CD47活性的治疗潜力.
  • 考虑对自身免疫性疾病和癌症的影响.

主要方法:

  • 对CD47.7.的现有文献的审查.
  • 分析CD47作为受体-连接体相互作用的结点的位置.
  • 考虑受CD47.7影响的信号通路.

主要成果:

  • CD47 由于其广泛的受体-多重质子网络,表现出 pleiotropic 效应.
  • CD47调节的目标效应经常被忽视.
  • CD47作为受体的连接器和信号通路的双重作用影响着各种细胞类型.

结论:

  • CD47调制 (阻断和增强) 的临床实用性需要进一步研究.
  • CD47的复杂功能为治疗干预带来了挑战和机会.
  • 向CD47可能为自身免疫性疾病和癌症治疗提供潜在的好处.