素涂层的蛋白质多醇微载体用于配送大吉素
Su Hui Lim1, Germaine Jia Min Yong1,2, Cheryl Yingxue Chia1
1Singapore Institute of Food and Biotechnology Innovation (SIFBI), Agency for Science, Technology and Research (A*STAR), 31 Biopolis Way, #01-02 Nanos, Singapore 138669. Lim_Su_Hui@sifbi.a-star.edu.sg.
Food & function
|February 16, 2024
概括
新的微载体保护大吉素,一个异黄,从上肠道吸收. 这增强了它向结肠的输送,由肠道细菌转化为equol,提高了生物可用性.
科学领域:
- 生物材料工程 生物材料工程
- 营养药物输送系统 营养药物输送系统
- 肠道微生物群的相互作用
背景情况:
- 豆类异黄之一的daidzein由于肠道上部吸收而具有有限的生物可用性.
- 肠道微生物群的殖民对于大吉素的代谢成为生物活性化合物等至关重要.
- 开发绕过上肠道吸收的策略是提高大吉素结肠功效的关键.
研究的目的:
- 设计粘素涂层蛋白质-素多层微载体,以增强大肠传递大素.
- 评估这些微载体对上部胃肠道消化的保护作用.
- 为了证明大肠中的大idzein的释放和转化为equol.
主要方法:
- 戴泽因被装入多孔碳酸微粒中.
- 一层一层的沉积在微粒上产生了素涂层的蛋白质-素多层薄膜.
- 使用了体外消化模型 (INFOGEST) 和用便微生物群进行结肠发酵.
主要成果:
- 功能化碳酸微粒实现了高的载荷能力 (21.6%).
- 素涂层的微载体在模拟的上肠消化过程中显著保护了大idzein (最高可保持71%).
- 结肠研究证实了肠道微生物群 (包括Slackia equolifaciens) 释放和转化为equol的daidzein.
结论:
- 素涂层蛋白质-素多层微载体有效地保护daidzein免受上肠降解.
- 这种输送系统增强了daidzein在结肠代谢中的潜力.
- 开发的微载体技术有望改善其他疏水性营养品和治疗药物的生物可访问性.
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