Dendrobium officinale花的局部提取物可以改善皮肤的氧化应激和衰老
Xing-Li-Shang He1,2, Ning Wang1,2, Xi Teng1,2
1Collaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals, Zhejiang University of Technology, Huzhou, Zhejiang, PR China.
Journal of cosmetic dermatology
|February 16, 2024
概括
丹德罗 (Dendrobium officinale) 花 (DOF) 通过清除自由基和提高皮肤质量,显示出显著的抗衰老特性. 这项研究证实了DOF的存在.
科学领域:
- 药理学 药理学是指药理学的学科.
- 皮肤病学 皮肤病学
- 生物化学 生化学
背景情况:
- 传统上,Dendrobium officinale花 (DOF) 被认为具有抗衰老和阴滋养作用.
- 有限的药理学研究存在于DOF对皮肤衰老的影响.
研究的目的:
- 用一个集成的体外,动物和人体模型来研究DOF在延缓皮肤衰老方面的有效性.
- 为了阐明DOF的抗皮肤衰老作用背后的抗氧化机制.
主要方法:
- 在体外抗氧化剂测试 (DPPH,基,超氧化基清理).
- 用D-银糖诱导的老鼠老化模型来评估血清和皮肤生物标志物.
- 人类临床试验评估面部皮肤老化参数上的局部DOF应用.
主要成果:
- 在实验室中,DOF表现出显著的自由基清除活性.
- 在老化小鼠中,DOF的使用增加了抗氧化酶活性 (T-AOC,SOD,CAT,GSH Px),GSH和Hyp,同时降低了MDA并激活了Keap1/Nrf2通路.
- 局部DOF应用改善了皮肤的水分,弹性,并减少了纹,毛孔,和紫外线斑点.
结论:
- DOF有效地减轻氧化应激引起的皮肤衰老.
- DOF的抗皮肤衰老机制涉及自由基清除和皮肤质量的直接改善.
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