开发和描述硫沙立方体对潜在的通过皮肤递送药物的特性
Mekha Mathew1, Anasuya Patil1, Hemanth G1
1Department of Pharmaceutics, KLE College of Pharmacy, Rajajinagar, Bengaluru, India.
Pharmaceutical nanotechnology
|February 16, 2024
概括
与口服方法相比,通过皮肤输入的硫沙拉载体立方体为类风湿性关节炎提供了一个有前途的局部治疗方法,改善了药物输送和疗效.
科学领域:
- 制药科学 制药科学
- 药物输送系统 药物输送系统
- 纳米技术 纳米技术
背景情况:
- 类风湿性关节炎是一种进展性自身免疫性疾病,会影响突膜,导致关节疼痛和胀.
- 苏尔法萨拉是一种BCS IV类药物,具有较差的溶解性和透性,限制了口服治疗疗效.
- 立方体被探索为一种通过皮肤递送药物系统,以增强局部药物效果并克服硫沙的局限性.
研究的目的:
- 开发和评估用于局部性类风湿性关节炎治疗的通过皮肤的硫沙拉载入的立方体体.
- 通过一种新的透皮方法来改善口服硫法萨拉的局限性.
主要方法:
- 用硫素加载的立方体体是使用糖单酸盐 (GMO) 和Poloxamer 407.7的自上而下的方法制造的.
- 为了优化脂质和表面活性剂度,采用了3 ^ 2的全因数设计.
- 配方进行了全面的表征,包括粒子大小,泽塔潜力,捕获效率,FTIR,SEM,体外释放和体外透研究.
主要成果:
- 立方体呈现的粒子大小在65-129nm之间,负泽塔电位 (-18.8到-24.8mV).
- 捕获效率很高,在87%至95%之间.
- 优化的配方在12小时内显示出受控的体外药物释放,与硫沙拉悬浮剂相比,具有更好的活体透和沉积.
结论:
- 通过皮肤输送含硫沙拉的立方体体,为治疗类风湿性关节炎提供了一个可行的策略.
- 这种方法具有局部治疗效果和改善患者治疗结果的潜力.
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