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Updated: Jul 3, 2025

Characterize Disease-related Mutants of RAF Family Kinases by Using a Set of Practical and Feasible Methods

Characterize Disease-related Mutants of RAF Family Kinases by Using a Set of Practical and Feasible Methods

Published on: July 17, 2019

在不同BRAF突变状态的I期肺腺癌患者之间有预后差异吗?

Shang-Shang Ma¹, Rang-Rang Wang¹, Qiao Peng²

¹Department of Thoracic Surgery, Shanghai Pulmonary Hospital, School of Medicine, Tongji University, Shanghai, P. R. China.

Thoracic cancer

|February 16, 2024

概括

BRAF突变不会显著影响早期肺腺癌 (LUAD) 的预后. 这项研究发现BRAF状态与I阶段LUAD患者的无复发生存率之间没有关联.

科学领域:

在瘤学瘤学.
基因组学就是基因组学.
癌症研究癌症研究

背景情况:

关于V-Raf小鼠肉瘤病毒性瘤基因同类B1 (BRAF) 突变在早期肺腺癌 (LUAD) 的预后作用的数据有限.
了解BRAF突变患病率及其影响对于LUAD的治疗策略至关重要.

研究的目的:

在I阶段的LUAD患者中调查BRAF突变的比例和临床病理特征.
为了确定BRAF突变对I阶段LUAD无复发生存 (RFS) 的预后意义.

主要方法:

来自cBioPortal的431名I阶段LUAD患者和上海肺部医院的1604名LUAD患者的分析.
使用卡普兰-梅尔曲线,日志等级测试,考克斯比例危险模型,倾向-得分匹配 (PSM) 和重叠权重 (OW) 进行生存分析.
评估的主要终点是无复发生存期 (RFS).

主要成果:

在5.6%的高加索人群中发现了BRAF突变;在1.4% (高加索人) 和1.0% (中国人) 的患者中发现了BRAF V600E突变.
在I阶段LUAD患者 (HR=1.111,p=0.885) 中,即使在PSM和OW之后,也没有发现BRAF突变和更糟糕的RFS之间的显著联系 (HR=1.111,p=0.885).
BRAF V600E突变状态也缺乏对RFS的预测意义.

结论:

BRAF突变状态似乎不是第一阶段肺腺癌的预后的重要预测因素.
需要进一步的研究和更大的数据集来验证这些发现及其临床影响.

关键词:

在BRAF V600E突变中.肺部腺癌的癌症在重叠的权重中,重量是重叠的.预后预后预后

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