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Updated: Jul 3, 2025

Phosphorus-31 Magnetic Resonance Spectroscopy: A Tool for Measuring In Vivo Mitochondrial Oxidative Phosphorylation Capacity in Human Skeletal Muscle
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通过破坏线粒体平衡和线粒体质量控制系统,导致FARS2缺乏心肌病

Bowen Li1, Fangfang Liu2, Xihui Chen1

  • 1Department of Biochemistry and Molecular Biology, Shaanxi Provincial Key Laboratory of Clinical Genetics (B.L., X.C., T.C., J.Z., Y.L., Y.Y., W.H., M.Z., Y.W.), Air Force Medical University, Xi'an, China.

Circulation
|February 16, 2024
PubMed
概括

在FARS2 (线粒体fenilalanyl- tRNA合成酶) 的遗传变异与高性心肌病 (HCM) 有关. 缺少FARS2会损害线粒体功能,导致心力衰竭,并为HCM提供新的诊断和治疗途径.

关键词:
自食症心肌疾病心脏衰竭线粒体动力学线粒体功能障碍氨-tRNA合成酶tRNA氨基化

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