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亨廷顿病在亚洲的流行:一个系统的审查和元分析

Basavaraja Papanna¹, Carlo Lazzari², Marco Rabottini³

¹Department of General Adult Psychiatry, Essex Partnership University Foundation Trust, Essex, United Kingdom.

Rivista di psichiatria

|February 16, 2024

概括

亨廷顿病 (HD) 对亚洲人群的影响较少于西方人群,在中国患病率最低. 这种差异可能是由于亚洲人群的社会耻辱,缺乏测试和遗传因素.

科学领域:

神经学神经学
流行病学流行病学
遗传学是一个遗传学.

背景情况:

流行病学研究表明,与西方人群相比,亚洲人群的亨廷顿病 (HD) 患病率较低.
本系统性审查旨在比较HD对亚洲人口的影响.

研究的目的:

系统地审查和分析有关亚洲亨廷顿病 (HD) 患病率的流行病学研究.
为了比较亚洲人口和西方国家的HD流行率.

主要方法:

使用Embase,Medline和PsychInfo数据库对亚洲疾病流行率的原始文章和评论进行系统审查.
对患病率的元分析,计算每10万人口的点患病率 (PP) 以95%信心区间 (CI95) 计算.

主要成果:

中东地区的HD点患病率最高 (PP=4.0,CI95=2.90-5.30).
中国人口的流行率最低 (PP=0.25,CI95=0.16-0.36).
亚洲的总体流行率是PP=0.70 (CI95=0.44-1.0),明显低于欧洲的PP=1.00 (CI95=0.82-1.19).

结论:

亨廷顿病对亚洲人口的影响比欧洲人口的影响要小.
患病率较低的潜在原因包括社会耻辱,对婚姻影响的恐惧以及对遗传/神经测试的限制.
遗传因素,如特定的CAG重复子组和C单元组,可能导致亚洲人与白人相比更低的HD倾向.

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