精神分裂型人格障碍的遗传流行病学
Kenneth S Kendler1,2, Henrik Ohlsson3, Jan Sundquist3,4,5
1Department of Psychiatry, Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, VA, USA.
精神分裂性人格障碍 (SPD) 与精神分裂症有关,并且与自闭症谱系障碍 (ASD) 和多动症 (ADHD) 共享遗传风险. 与ASD,ADHD和严重抑郁症的并发症可能会降低精神分裂症进展风险.
科学领域:
- 精神病学是一个精神病学.
- 遗传学 遗传学是一种遗传学.
- 流行病学 流行病学
背景情况:
- 精神分裂性人格障碍 (SPD) 概念起源于精神分裂症患者的亲属.
- 在流行病学样本中对SPD的研究有限,特别是使用遗传测量.
研究的目的:
- 在大型流行病学样本中调查SPD的患病率,并发病率和遗传风险因素.
- 评估从SPD发展为精神分裂症 (SZ) 的风险.
主要方法:
- 分析了2292名被诊断患有SPD (没有先前SZ) 的瑞典人群.
- 人口统计数据,并发病症和家庭遗传风险评分 (FGRS) 从国家注册表中提取.
- 考克斯模型被用来预测SZ发展.
主要成果:
- SPD患病率为0.044%,与自闭症谱系障碍 (ASD),强迫症,多动症和严重抑郁症 (MD) 的高并发症率.
- 患有SPD的个体显示SZ,ASD,MD和ADHD的FGRS升高.
- 14.6%的SPD病例进展为SZ,风险受遗传因素,性别,年龄和诊断类型的影响,但因MD,ASD和ADHD的并发症而减少.
结论:
- 这些发现支持将SPD归类在精神分裂症谱中.
- 建议SPD和ASD,ADHD,强迫症和MD之间存在显著的病因联系.
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