微生物群在肝病中的作用
David Schöler1, Bernd Schnabl1,2
1Department of Medicine, University of California, San Diego.
Current opinion in gastroenterology
|February 16, 2024
概括
肠肝轴和肠道微生物群显著影响肝脏健康. 干扰会导致MASLD,ALD,AILD和HCC等肝脏疾病,促使开发新的以微生物为中心的疗法.
科学领域:
- 微生物学 微生物学
- 肝病学 肝病学是一种肝病学.
- 胃肠病学 胃肠病学
背景情况:
- 肠道微生物组和肠肝轴对于维持健康和疾病状态至关重要.
- 肠道中的微生物失衡可以导致或加剧肝脏疾病.
- 本综述侧重于最近关于微生物组在代谢功能障碍相关的脂肪性肝病 (MASLD),酒精相关的肝病 (ALD),自身免疫性肝病 (AILD) 和肝细胞癌 (HCC) 中的作用的进展.
研究的目的:
- 总结一下最近在理解肠道微生物组在肝脏疾病中的作用方面取得的进展.
- 专注于代谢功能障碍相关的脂肪性肝病 (MASLD),酒精相关的肝病 (ALD),自身免疫性肝病 (AILD) 和肝细胞癌 (HCC).
主要方法:
- 关于肠肝轴和肝脏疾病的最新科学文献 (过去3年) 的综述.
- 对调查便病毒组和菌组变化的研究进行分析.
- 检查与肝病相关的微生物代谢物和毒性因子.
主要成果:
- 在各种肝脏疾病中观察到便病毒和真菌生物组的变化.
- 微生物代谢物,包括内源性乙醇和细菌毒性因子,与MASLD,ALD,AILD和HCC有机械联系.
- 针对微生物组的治疗方法,如菌体,益生菌,后生菌和便微生物群移植,在临床前和临床环境中表现有前途.
结论:
- 肠肝轴是肝脏疾病病理生理学的核心.
- 了解肠道微生物群对于开发针对性,以微生物群为重点的肝病治疗干预措施至关重要.
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