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晶体细胞脑后缺血/再输血中的代谢重编程:从病理生理学到治疗潜力

Lipeng Gong1, Junjie Liang1, Letian Xie1

  • 1Key Laboratory of Hunan Province for Integrated Traditional Chinese and Western Medicine on Prevention and Treatment of Cardio-Cerebral Diseases, College of Integrated Traditional Chinese Medicine and Western Medicine, Hunan University of Chinese Medicine, Changsha, Hunan 410208, China.

Current neuropharmacology
|February 16, 2024
PubMed
概括

微质细胞和星体细胞等质细胞中的代谢重编程是治疗缺血性中风后再注射损伤的关键. 针对这些代谢转变为脑损伤提供了新的治疗策略.

关键词:
缺血性中风是因为缺血性中风.大脑缺血/反损伤质细胞 (gliocyte) 是一种细胞.代谢重编程是指代谢重编程.氧化压力.氧化压力.病理生理学 病理生理学

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An ischemic stroke occurs when a cerebral blood vessel becomes obstructed, most often by a thrombus or embolus, interrupting the delivery of oxygen and glucose to brain tissue. Because neurons rely on continuous aerobic metabolism, energy failure begins within minutes of reduced perfusion. The region receiving the least blood flow becomes the infarct core, an area of irreversible cellular death. Surrounding this core lies the penumbra, a zone of hypoperfused but still viable tissue that is...