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关于儿童牛奶过敏的当前见解:微生物组,代谢组和免疫反应 - - 一项系统性审查

Mariyana V Savova¹, Pingping Zhu¹, Amy C Harms¹

¹Metabolomics and Analytics Centre, Leiden Academic Centre for Drug Research, Leiden University, Leiden, The Netherlands.

Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology

|February 16, 2024

概括

儿童牛奶过敏 (CMA) 与肠道微生物组 (GM) 变化有关,有益细菌和短链脂肪酸 (SCFA) 减少. 益生菌干预措施在恢复转基因平衡和免疫反应方面表现有前途.

科学领域:

免疫学免疫学免疫学
微生物学微生物学
儿科儿科儿科

背景情况:

通过IgE介导的牛奶过敏 (CMA) 是儿童日益严重的全球健康问题.
肠道微生物组 (GM) 越来越多地被认为在CMA发展中的作用.
益生菌和益生菌干预正在获得CMA管理的引力.

研究的目的:

在儿童和动物模型中系统地审查肠道微生物组,代谢组和免疫反应的变化.
检查益生菌和益生菌干预对CMA的转基因和相关途径的影响.
确定研究缺口,以开发有效的CMA治疗和预防策略.

主要方法:

在MEDLINE,PubMed,Scopus和Web of Science的系统文献搜索中,寻找在CMA诊断的儿童和动物模型中对转基因的研究.
包括2023年3月1日之前发表的21篇文章 (13篇关于儿童,8篇关于动物模型).
对肠道微生物组合,代谢 (包括SCFA) 和免疫反应的分析.

主要成果:

生命早期的CMA与基因转基因有关,其特点是Clostridia增加和Lactobacillales和Bifidobacterium减少.
患有CMA的儿童表现出减少的短链脂肪酸 (SCFA) 和改变的氨基酸代谢.
益生菌干预,主要使用Bifidobacterium和Lactobacillus,显示出恢复Bifidobacterium水平,SCFA生产和氨基酸平衡的潜力,以及调节动物模型中的免疫反应.

结论:

肠道微生物群在牛奶过敏的发病过程中起着重要作用.
益生菌干预表明有可能恢复肠道微生物组平衡并改善CMA中的免疫反应.
进一步的多主题研究对于机械的理解和针对CMA的向治疗的开发至关重要.

关键词:

牛奶过敏是因为牛奶过敏.我们的肠道微生物群.免疫反应的免疫反应.婴儿婴儿婴儿婴儿代谢生物组的代谢生物组鼠标模型鼠标模型鼠标模型综合生物 synbiotics 综合生物

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