在人类健康和疾病中重新审视Chaperonin T-复合蛋白-1环复合物:蛋白质稳定调节器及其他方面
Chenglong Zeng1,2,3, Shenqi Han1,2,3, Yonglong Pan1,2,3
1Hepatic Surgery Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Clinical and translational medicine
|February 16, 2024
概括
蛋白质平衡中断与疾病有关. T复合蛋白-1环复合体 (TRiC/CCT) 对于蛋白质折叠和蛋白质稳定至关重要,对各种疾病和潜在的临床应用有影响.
科学领域:
- 细胞生物学 细胞生物学
- 生物化学 生物化学
- 分子医学是分子医学.
背景情况:
- 蛋白质稳态 (蛋白质稳态) 的破坏是各种疾病的标志.
- 细胞体T复合蛋白-1环复合体 (TRiC/CCT) 通过折叠蛋白质来维持蛋白质静止,指导局部化和防止聚合是必不可少的.
- 研究已经阐明了TRiC/CCT在生理和病理过程中的作用.
研究的目的:
- 审查TRiC/CCT的动态蛋白质折叠周期.
- 详细介绍TRiC/CCT在细胞过程中的参与,如细胞循环调节,细胞亡和免疫.
- 探索TRiC/CCT在疾病发病,特别是癌症中的作用,并讨论转化潜力.
主要方法:
- 对TRiC/CCT功能和机制的文献综述.
- 分析TRiC/CCT在各种细胞通路中的作用.
- 汇编了TRiC/CCT相关疾病及其分子基础.
主要成果:
- TRiC/CCT控制了基质选择,识别和蛋白质折叠.
- TRiC/CCT涉及细胞循环,细胞亡,自,新陈代谢,免疫和信号传导.
- TRiC/CCT功能障碍与神经病变,心血管疾病,恶性瘤和癌症进展有关.
结论:
- TRiC/CCT是蛋白质稳定的一个关键调节器,具有广泛的细胞功能.
- TRiC/CCT在许多疾病的发展和进展中起着重要作用.
- 需要对TRiC/CCT机制进行进一步的研究,以便在诊断和治疗中进行临床转化.
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