免疫细胞和炎症介质在血管微生理系统中引起内皮功能障碍
Aishwarya Rengarajan1,2, Hannah E Goldblatt1,2, David J Beebe3,4,5
1Department of Obstetrics & Gynecology, University of Wisconsin-Madison, School of Medicine and Public Health, USA. dsboeldt@wisc.edu.
Lab on a chip
|February 16, 2024
概括
这项研究表明,炎症媒介和激活的免疫细胞导致内皮功能障碍,影响血管健康. 微生理系统 (MPS) 有效地模拟这些影响,用于潜在的治疗选.
科学领域:
- 心血管科学 心血管科学
- 免疫学 免疫学 免疫学
- 生物医学工程 生物医学工程
背景情况:
- 内皮功能障碍是诸如高血压和动脉样硬化等血管疾病的关键因素.
- 免疫系统失调,包括炎症性细胞因子,有助于内皮功能障碍.
- 评估内皮功能对于了解血管健康至关重要.
研究的目的:
- 使用3D血管微生理系统 (MPS) 评估内皮功能.
- 研究炎症媒介和免疫细胞对内皮功能的影响.
- 建立心血管疾病研究和药物查的模型.
主要方法:
- 使用人类静脉内皮细胞 (HUVECs) 开发3D血管MPS.
- 评估内皮膜的透性和Ca2+信号传递.
- MPS暴露于炎症因子 (TNFα,VEGF-A,IL-6) 和外周血液单核细胞 (PBMCs) 的影响.
主要成果:
- 炎症调解剂破坏了内皮屏障,并减少了Ca2+信号传递.
- 激活的PBMCs显著增加了内皮通透性和降低了Ca2+活性.
- MPS有效地模拟了由炎症诱导的内皮功能障碍.
结论:
- 血管MPS是研究心血管疾病中的内皮功能障碍的宝贵工具.
- 炎症媒介和免疫细胞在损害内皮屏障完整性和功能方面发挥着关键作用.
- 这种模型对选新型治疗干预措施充满希望.
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