在内镜和开放的手腕道释放中amyloid沉积的比较
Yagiz Ozdag1, Jessica L Koshinski1, Brendan J Carry2
1Department of Orthopaedic Surgery, Geisinger Musculoskeletal Institute, Geisinger Commonwealth School of Medicine, Danville, PA.
The Journal of hand surgery
|February 16, 2024
概括
内镜道释放 (ECTR) 显示,与开放式道释放 (OCTR) 相比,粉样沉积的发生率较低. 在手腕道手术期间,外科医生可能会考虑采用开放式方法进行活检.
科学领域:
- 整形外科手术 整形外科手术
- 神经学 神经学
- 病理学 病理学 病理学
背景情况:
- 交叉手腕带 (TCL) 中的粉样蛋白沉积是手腕道综合征的一种已知的并发症.
- 之前关于在手腕道释放 (CTR) 期间粉样蛋白检测的研究主要集中在开放CTR (OCTR) 上.
- 人们对内镜CTR (ECTR) 中活检的技术可行性和诊断产量存在担忧.
研究的目的:
- 为了比较ECTR与OCTR期间通过活检检测到的粉样蛋白沉积的发生率.
- 评估粉样蛋白检测在CTR不同手术方法中的有效性.
主要方法:
- 从2022年2月到2023年6月,对282种使用粉样蛋白活检的初级ECTR和OCTR手术进行了回顾性审查.
- 刚果红色染色用于TCL或tenosynovium中的粉样蛋白检测.
- 亚型分析和蛋白质识别通过液体染色学 - 阳性病例的并联质谱学.
主要成果:
- 总共分析了282个病例 (143个ECTR,139个OCTR).
- 总体而言,13%的CTR病例显示出阳性粉样蛋白活检.
- 在3.5%的ECTR病例中检测到amyloid沉积,而OCTR病例中只有23%,这是统计学上显著的差异.
结论:
- 与OCTR相比,ECTR期间的活检可能会产生较低的粉样蛋白检测发生率.
- 需要进行进一步的研究,以探索手术方法之间的tenosynovium组织学差异.
- 开放的方法可能有利于在手腕道释放期间计划粉样蛋白活检的外科医生.
相关概念视频
Amyloid Fibrils
Amyloid fibrils are aggregates of misfolded proteins. Under most circumstances, misfolded proteins are either refolded by chaperone proteins or degraded by the proteasome. However, in the case of a mutation or a disease, these proteins can accumulate to form large clusters and often further assemble to form elongated fibers, called fibrils.
Amyloid deposits were observed as early as 1639 in the liver and the spleen. In 1854, Rudolph Virchow performed iodine staining, normally used to...
Amyloid deposits were observed as early as 1639 in the liver and the spleen. In 1854, Rudolph Virchow performed iodine staining, normally used to...
Amyloid Fibrils
Amyloid fibrils are aggregates of misfolded proteins. Under most circumstances, misfolded proteins are either refolded by chaperone proteins or degraded by the proteasome. However, in the case of a mutation or a disease, these proteins can accumulate to form large clusters and often further assemble to form elongated fibers, called fibrils.
Amyloid deposits were observed as early as 1639 in the liver and the spleen. In 1854, Rudolph Virchow performed iodine staining, normally used to...
Amyloid deposits were observed as early as 1639 in the liver and the spleen. In 1854, Rudolph Virchow performed iodine staining, normally used to...


