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Updated: Jul 3, 2025

A Faster, High Resolution, mtPA-GFP-based Mitochondrial Fusion Assay Acquiring Kinetic Data of Multiple Cells in Parallel Using Confocal Microscopy
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Published on: July 20, 2012

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PP2A和GSK3通过调节线粒体运输来作为FUS-ALS的修饰剂

Paraskevi Tziortzouda1,2, Jolien Steyaert1,2, Wendy Scheveneels1,2

  • 1Department of Neurosciences, Experimental Neurology and Leuven Brain Institute (LBI), KU Leuven-University of Leuven, Leuven, Belgium.

Acta neuropathologica
|February 16, 2024
PubMed
概括

一项新的研究确定了蛋白酸酶2A (PP2A) 和糖原合成酶激酶3 (GSK3) 作为FUS-氨型侧面硬化症 (ALS) 的关键修饰剂. 抑制这些蛋白质可以挽救FUS-ALS毒性和相关的神经元缺陷.

关键词:
肌缩性侧面硬化症 (AMLS) 是一种疾病.这种植物是Drosophila.这是GSK3的GSK3.这种类型的激素是kinesin.在PP2A中,PP2A是PP2A.

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