代谢风险因素与西班牙裔患者晚期腺瘤的关联
Robert Tamai1, Lillian Dawit1, Patrick Lee1
1Division of Gastroenterology and Hepatology, Department of Medicine, Keck School of Medicine of USC, HCC 261 1510 San Pablo Street, Health Sciences Campus, Los Angeles, CA, 90089, USA.
Digestive diseases and sciences
|February 16, 2024
概括
患有肥胖和高甘油三醇的西班牙裔患者面临着晚期结直肠腺瘤的风险增加. 针对体重管理和代谢健康的早期干预对于预防这种人群的结直肠癌至关重要.
科学领域:
- 胃肠病学 胃肠病学
- 在瘤学瘤学.
- 代谢健康 代谢健康
背景情况:
- 肥胖和代谢综合征 (MetS) 与增加结直肠癌 (CRC) 风险有关.
- 西班牙裔人口中肥胖率的上升可能会增加他们患晚期结直肠瘤的风险.
- 目前对这一人口群体中CRC风险因素的研究有限.
研究的目的:
- 在西班牙裔美国人中确定与晚期腺瘤 (AA) 相关的代谢风险因素.
- 在西班牙裔群体中调查肥胖,代谢综合征和结直肠瘤之间的联系.
主要方法:
- 无症状的西班牙裔患者 (年龄大于45岁) 的回顾性审查,在便血液检测阳性后进行初始结肠镜检查.
- 收集的数据包括人口统计,代谢特征,多体大小和组织学.
- 多变量逻辑回归分析了晚期腺瘤的相对风险 (AA).
主要成果:
- 16%的患者患有晚期腺瘤 (AA).
- 较高的BMI (>34.9 kg/m2),男性性别和高的甘油三与AA风险增加有关.
- 糖尿病,高血压和HDL-C水平与AA风险没有显著关联.
结论:
- 具有便血液检测阳性的西班牙裔患者表现出AA的高发病率.
- 二级肥胖 (BMI ≥35 kg/m2) 和高甘油三是男性AA的重要危险因素.
- 诸如多学科体重管理计划之类的干预措施可以通过解决可修改因素来降低CRC风险.
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