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Updated: Jul 2, 2025

Studying TGF-β Signaling and TGF-β-induced Epithelial-to-mesenchymal Transition in Breast Cancer and Normal Cells
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Published on: October 27, 2020

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通过增强AXIN1介导的Smad7降解,TRAF2降低促进了MAFLD-HCC中的TGF-β-mTORC1信号

Zhonglin Li1, Jinfang Zhao1, Ya Wu2

  • 1Division of Gastroenterology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology
|February 16, 2024
PubMed
概括

瘤坏死因子受体相关因子2 (TRAF2) 缺乏通过增强TGF-β-mTORC1通路,促进代谢相关的脂肪肝疾病 (MAFLD) 和肝细胞癌 (HCC). 减少TRAF2加速了MAFLD-HCC中的瘤生长.

关键词:
在AXIN1中,AXIN1是AXIN1的前身.马夫尔德 (MAFLD) 是一个在TGF-β的基础上.在TRAF2中,肝炎肝炎是一种肝炎.在 mTORC1 的情况下,mTORC1 是 mTORC1.

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