患有急性淋巴细胞白血病或淋巴瘤的儿科患者的COVID-19
Saman K Hashmi1,2, Jessica Bodea1, Tushar Patni3
1Department of Oncology, St Jude Children's Research Hospital, Memphis, Tennessee.
JAMA network open
|February 16, 2024
概括
在患有急性淋巴细胞白血病或淋巴瘤 (ALL/LLy) 的儿科患者中,COVID-19是罕见的和严重的,但大多数患者经历了化疗中断. 需要进一步的研究来了解长期的结果.
科学领域:
- 儿科瘤学 儿科瘤学
- 传染性疾病 传染性疾病
- 血液学 血液学 血液学
背景情况:
- 患有急性淋巴细胞白血病或淋巴瘤 (ALL/LLy) 的儿科患者的COVID-19需要详细了解,因为它可能对治疗和结果产生影响.
- 化疗管理和长期结果可能会受到COVID-19在这个脆弱人群的影响.
研究的目的:
- 描述COVID-19在患有ALL/LLy.Ly的儿科患者的临床表现.
- 在COVID-19大流行期间记录ALL/LLy儿科患者的化疗修改.
主要方法:
- 儿科患者 (1-18岁) 的回顾病例系列,新诊断的ALL/LLy接受了总体XVII协议的治疗.
- 在27个月的时间内评估COVID-19症状,化疗修改,病毒清除,不良事件和SARS-CoV-2再感染.
主要成果:
- 在308名儿科患者中,110名 (36%) 感染了COVID-19. 严重的疾病是罕见的 (6%),与年龄较大和淋巴细胞数量较低有关.
- 化学疗法中断发生在87%的患者身上,对于那些患有严重疾病或SARS-CoV-2再感染的人来说,延迟时间更长.
- 在10%的患者中发生了SARS-CoV-2再感染,这与年龄较大和风险较高的ALL/LLy治疗有关.
结论:
- 严重的COVID-19在儿科ALL/LLy患者中不常见,但大多数患者经历了化疗中断.
- 化疗修改是频繁的,突出显示了疫情期间需要谨慎管理的必要性.
- 长期研究对于确定COVID-19在儿科ALL/LLy患者的最终结果至关重要.
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