运动诱导的心脏托波素释放在有冠状动脉样硬化或没有冠状动脉样硬化的运动员中
Sylvan L J E Janssen1, Femke de Vries1, Alma M A Mingels2
1Department of Medical BioSciences, Radboud University Medical Center, Nijmegen, The Netherlands.
American journal of physiology. Heart and circulatory physiology
|February 16, 2024
概括
与健康的同龄人相比,中年运动员患有冠状动脉样硬化并没有表现出更大的运动诱导的心脏类素 (cTn) 释放. 冠状动脉分数或狭窄症在耐力运动后不会加剧cTn释放.
科学领域:
- 心脏病学 心脏病学
- 运动生理学 运动生理学
- 生物标志物 生物标志物
背景情况:
- 运动诱导的心脏热素 (cTn) 升高取决于心血管健康.
- 隐形冠状动脉样硬化在运动员中很常见.
- 动脉样硬化对老年运动员运动诱导的cTn释放的影响尚不清楚.
研究的目的:
- 为了测试中年和年长的冠状动脉样硬化运动员在耐力运动后是否表现出较大的cTn升高,与健康运动员相比.
- 为了研究冠状动脉分数 (CACS) 或显著的冠状动脉狭窄和运动诱导的CTn释放之间的关系.
主要方法:
- 59名男性运动员被分类为控制 (CACS=0),高CACS (≥300AU或≥75MESA百分位数) 或显著狭窄 (≥50%) 组.
- 参与者进行了受控的增量自行车运动测试,以达到意志疲劳.
- 在运动前,运动期间和运动后长达180分钟的时间内,测量了连续高灵敏性心脏热素T (hs-cTnT) 和I (hs-cTnI) 水平.
主要成果:
- 运动时间和工作量在所有组中都相似.
- 在所有参与者中,hs-cTnT和hs-cTnI水平在运动后显著增加.
- 在患有冠状动脉样硬化和不患冠状动脉样硬化的运动员之间,没有观察到cTn变化模式或超过99百分位的度发生率的显著差异.
结论:
- 高CACS或显著的冠状动脉狭窄似乎不会加剧中年和老年运动员的运动诱导的cTn释放.
- 这些发现表明,冠状动脉样硬化的存在不会改变在该人群中耗尽耐力运动后cTn释放的幅度.
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