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一个血液动力学研究的血液流动模型在多种支架移植配置在动脉-阴茎重建期间的血流模型

Konstantinos Tzirakis¹, Nikolaos Kontopodis², Christos V Ioannou²

¹Department of Mechanical Engineering, School of Engineering, Hellenic Mediterranean University, Heraklion, Crete, Greece.

Clinical hemorheology and microcirculation

|February 16, 2024

概括

支架移植几何学显著影响腹腔大动脉动脉瘤的内血管修复结果,顶下芭蕾舞类型比非芭蕾舞设计表现出优越的血液动力学性能. 血流模型的效果是最小的.

科学领域:

生物医学工程生物医学工程
计算流体动力学的流体动力学.
医疗器械设计医疗器械设计

背景情况:

内血管动脉瘤修复 (EVAR) 依赖于支架移植来治疗腹腔大动脉动脉瘤 (AAA).
优化支架移植设计对于改善长期临床结果和患者安全至关重要.
了解不同支架移植配置的血液动力学性能对于EVAR的成功至关重要.

研究的目的:

在EVAR期间比较三个理想化支架移植配置 (自下而上非芭蕾舞,自上而下非芭蕾舞,自上而下芭蕾舞) 的血液动力学性能.
评估各种血液风湿学模型在AAA修复中对支架移植性能的影响.

主要方法:

使用有限体积溶解器进行计算流体动力学 (CFD) 模拟.
在现实的边界条件下分析了十种不同的风湿学模型.
计算关键的血液动力学变量:时间平均壁切削应力 (TAWSS),振荡切削指数 (OSI),相对停留时间 (RRT),内皮细胞激活潜力 (ECAP) 和位移力 (DF).

主要成果:

支架移植的几何学显著影响了血液动力学性能,比使用的风湿学模型更重要.
"自下而上"的非芭蕾舞配置表现出最不有利的血液动力学 (最低的TAWSS,最高的OSI,RRT,ECAP).
顶向下的芭蕾舞配置显示出优越的血液动力学优势 (最高的TAWSS,最低的OSI,RRT,ECAP).

结论:

支架移植形状的类型是EVAR整体血液动力学性能的主要决定因素.
风病学模型对对象移植设计的比较评估的影响有限.
顶下芭蕾舞支架移植设计显示了AAA修复的有希望的血液动力学特性.

关键词:

非牛顿式的血液流动.计算流体动力学的流体动力学.有限体积方法的有限体积方法.血液动力学参数血液动力学参数理想化的支架移植

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