使用韦克斯勒成人智力尺度评估中风后认知功能的预测者:一项回顾性研究
Wenlong Su1,2, Hui Li3,2,4, Hui Dang3,2,4
1China Rehabilitation Research Center, School of Rehabilitation, Capital Medical University, Beijing, China.
Journal of Alzheimer's disease : JAD
|February 16, 2024
概括
脑卒中后认知障碍 (PSCI) 受教育,病变侧面,失语,额叶和扩散性病变的影响. 阿法西亚显著调解严重PSCI的认知结果.
科学领域:
- 神经学 神经学
- 神经科学是一个神经科学.
- 医疗信息学 医疗信息学
背景情况:
- 脑卒中后的认知障碍 (脑卒中后认知障碍,PSCI) 呈现出复杂的机制,因此很难识别导致的因素.
- 了解这些因素对于开发有针对性的干预措施和改善患者治疗结果至关重要.
研究的目的:
- 量化评估临床指标对中风后认知障碍 (PSCI) 的影响和相互作用.
- 确定影响中风幸存者的认知功能的关键预测因素和调解变量.
主要方法:
- 对270名PSCI患者的数据进行了回顾性分析,包括18个指标和韦克斯勒成人智力量表 (WAIS-RC) 评分.
- 多种分析模型的应用:多重线性回归 (MLR),基因算法修改后传神经网络 (GA-BP),物流回归 (LR),XGBoost (XGB) 和结构方程建模 (SEM).
主要成果:
- 七个指标,包括教育,病变侧面,失语,额叶,叶,扩散性病变和疾病进程,与WAIS分数有显著的相关性.
- MLR,GA-BP,LR和XGB模型确定了教育,病变侧面,失语,额叶和扩散性病变作为PSCI的重要预测因素.
- 亚法西亚被确定为一个显著的调解变量,特别是在严重的PSCI患者中.
结论:
- 教育,病变侧面,失语,额叶参与和扩散性病变是显著影响PSCI的关键临床因素.
- 在中风后患者的临床因素和认知障碍严重程度之间的关系中,阿法西亚起着关键的调解作用.
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