后皮层缩后视觉通路的神经生理学变化:系统性审查和一系列病例
Matteo Cotta Ramusino1, Lucia Scanu2, Linda Gritti2
1Clinical Neuroscience Unit of Dementia, Dementia Research Center, IRCCS Mondino Foundation, Pavia, Italy.
Journal of Alzheimer's disease : JAD
|February 16, 2024
概括
后皮层缩 (PCA) 影响视觉通路,神经生理学测试显示了视觉唤起潜能 (VEP) 和正常电网红图 (ERG) 的改变. 这些发现表明PCA患者的视觉通路涉及广泛.
科学领域:
- 神经科学是一个神经科学.
- 眼科医生 眼科 眼科
- 神经学 神经学
背景情况:
- 后皮层缩 (PCA) 是一种罕见的神经退行性疾病,通常与阿尔茨海默病有关.
- 虽然已定义了临床特征,但它的神经生理基础,特别是视觉通路的基础,仍然不太清楚.
研究的目的:
- 调查和描述PCA患者视觉通路中的神经生理学变化.
- 使用视觉场测试 (VF),视觉唤起潜力 (VEP) 和电网红图 (ERG) 进行评估.
主要方法:
- 按照PRISMA指南进行系统的文献审查,选择报告PCA患者VF,VEP和ERG的研究.
- 包括来自17项已发表的研究 (140名患者) 和6名PCA患者的本地队列的数据.
主要成果:
- 文献审查显示,50%的患者患有同名的半视障碍;VEP和ERG的数据有限.
- 局部队列:50%有同名的半视眼;VEP显示67%的延迟增加,大多数的幅度正常,与缩严重程度相关.
- 在文献和本地队列中,电视网膜图 (ERG) 显示出一般正常的发现.
结论:
- 关于PCA视觉通路的神经生理学数据很少.
- 在PCA中存在VEP (幅度和延迟) 的变化,可能会影响一只或两只眼睛.
- 研究结果表明,在后皮层缩中,视觉通路的广泛,多点参与.
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