前性痴呆症的神经心理症状:不仅仅是噪音?
Daniele Altomare1, Jasmine Rivolta1, Ilenia Libri1,2
1Department of Clinical and Experimental Sciences, Neurology Unit, University of Brescia, Brescia, Italy.
Journal of Alzheimer's disease : JAD
|February 16, 2024
概括
在前性痴呆症 (FTD) 中,诸如易怒和抑郁症之类的神经精神症状很常见,即使在早期也是如此. 在FTD中,精神病可能表明更糟糕的结果,需要及时管理.
科学领域:
- 神经学 神经学
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
背景情况:
- 神经精神症状显著影响前性痴呆症 (FTD) 患者和照顾者的生活质量.
- 这些症状往往被低估,因为它们并不特定于FTD.
研究的目的:
- 确定FTD中神经精神症状的患病率,包括前阶段.
- 将这些症状与疾病严重程度,FTD特异性病理和临床结果联系起来.
- 识别FTD病理学独立的神经精神症状.
主要方法:
- 对461名FTD患者的回顾性分析 (行为变体FTD和初级渐进性失语症).
- 使用神经精神病 inventory 对神经精神病症状的评估.
- 用临床痴呆症评分加NACC FTLD尺度评估疾病严重程度和病期.
主要成果:
- 常见的前进性FTD症状包括易怒 (48%),抑郁 (35%) 和焦虑 (34%).
- 大多数症状严重程度与全球疾病严重程度相关.
- 精神病和情绪症状在很大程度上独立于FTD特异性症状. 精神病与年龄更大,严重程度更高,生存率降低有关.
结论:
- 神经精神症状在FTD中很普遍,即使在早期阶段.
- 精神病可能与FTD病理无关,并且与较差的结果有关.
- 早期发现和治疗这些症状可以改善患者的管理和生活质量.
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