在帕金森病中减轻压力:症状治疗,疾病修改,还是两者兼而有之?
Franziska Goltz1, Anouk van der Heide1, Rick C Helmich1
1Neurology Department, Donders Institute for Brain, Cognition and Behaviour, Centre of Expertise for Parkinson and Movement Disorders, Radboud University Medical Centre, Nijmegen, The Netherlands.
Journal of Parkinson's disease
|February 16, 2024
概括
压力管理干预措施有望缓解帕金森病 (PD) 的症状. 虽然生活方式的改变可能会减缓疾病的进展,但需要更多的人类研究来证实这些疾病修饰效应.
科学领域:
- 神经科学是一个神经科学.
- 心理学 心理学 心理学
- 医学研究 医学研究
背景情况:
- 心理压力显著影响帕金森病 (PD),恶化运动症状并加剧焦虑和抑郁等非运动症状.
- 动物模型表明,慢性压力可能会加速多巴胺细胞死亡,这表明通过压力减轻策略有可能改变疾病.
研究的目的:
- 为了确定有效的减轻帕金森病的压力策略.
- 分析这些干预措施对修改PD进展的潜力.
主要方法:
- 进行了非结构化的文献搜索,专注于2020年至2023年间发表的论文.
- 对PD症状进行有氧运动和基于正念的干预措施的临床试验进行了审查.
主要成果:
- 运动和正念干预措施减少与压力相关的PD症状的证据是有希望的,但不是确定性的.
- 许多试验缺乏对压力和疾病进展的生物测量,随访期往往太短,无法评估疾病的改变.
结论:
- 生活方式干预有效地减轻帕金森病中与压力相关的症状.
- 这些干预措施有可能改变疾病,但需要进一步的人体研究来验证这些影响并澄清潜在机制.
相关概念视频
Parkinson's Disease: Treatment
268
Neurodegenerative disorders, such as Parkinson's Disease (PD), involve the gradual and irreversible destruction of neurons in particular brain areas. These disorders exhibit standard features like proteinopathies, selective vulnerability of some neurons, and an interaction of intrinsic properties, genetics, and environmental influences in neural injury.
Parkinson's Disease is primarily a result of the loss of dopaminergic neurons in the substantia nigra pars compacta. The cornerstone of...
Parkinson's Disease is primarily a result of the loss of dopaminergic neurons in the substantia nigra pars compacta. The cornerstone of...
268
Parkinson's Disease: Overview
546
Neurodegenerative disorders are progressive diseases that cause irreversible damage and loss to neurons in specific brain areas. Examples of these disorders include Parkinson's disease, Alzheimer's disease, Multiple Sclerosis (MS), and Amyotrophic Lateral Sclerosis (ALS). These disorders share characteristics such as proteinopathies, selective neuronal vulnerability, and a complex interplay between genetic and environmental factors. The primary therapeutic goal for these conditions is...
546
Alzheimer's Disease: Treatment
189
Alzheimer's Disease (AD), a neurodegenerative disorder, is pathologically identified by amyloid plaques and neurofibrillary tangles composed of tau protein. AD pharmacotherapy aims to manage cognitive symptoms, delay disease progression, and treat behavioral symptoms. The treatment is primarily symptomatic and palliative, with no definitive disease-modifying therapy available. Cholinesterase inhibitors, including donepezil (Aricept), rivastigmine (Exelon), and galantamine (Razadyne), are...
189
Stress Prevention and Stress Management Techniques III
61
Regular exercise and meditation serve as essential tools in managing stress and promoting physical and mental well-being.
The Role of Exercise in Stress Management
Regular physical activity is essential for reducing stress and promoting cardiovascular health. Exercise strengthens the heart, enhances blood flow, keeps blood vessels flexible, and helps lower blood pressure, all of which reduce the body's stress response. Research shows that adults who exercise regularly have nearly half the...
The Role of Exercise in Stress Management
Regular physical activity is essential for reducing stress and promoting cardiovascular health. Exercise strengthens the heart, enhances blood flow, keeps blood vessels flexible, and helps lower blood pressure, all of which reduce the body's stress response. Research shows that adults who exercise regularly have nearly half the...
61
Stress Prevention and Stress Management Techniques VI
32
Adopting a healthier lifestyle often requires overcoming significant challenges, but leveraging psychological, social, and cultural resources can facilitate meaningful change. Effective self-change hinges on understanding and applying key tools such as motivation and goal setting, which help sustain efforts toward long-term health benefits.
Motivation and Self-Determination
Motivation, the driving force behind behavior, plays a pivotal role at every stage of the change process. The research...
Motivation and Self-Determination
Motivation, the driving force behind behavior, plays a pivotal role at every stage of the change process. The research...
32
Neural Regulation
39.4K
Digestion begins with a cephalic phase that prepares the digestive system to receive food. When our brain processes visual or olfactory information about food, it triggers impulses in the cranial nerves innervating the salivary glands and stomach to prepare for food.
39.4K


