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Updated: Jul 2, 2025

Tumor Transplantation for Assessing the Dynamics of Tumor-Infiltrating CD8+ T Cells in Mice
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Tumor Transplantation for Assessing the Dynamics of Tumor-Infiltrating CD8+ T Cells in Mice

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在瘤微环境中,类似干细胞的祖先和终端分化的TFH类似CD4+的T细胞耗尽

Wenhao Zhou1, Shusuke Kawashima2, Takamasa Ishino3

  • 1Department of Tumor Microenvironment, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama 700-8558, Japan; Department of Immunology, Nagoya University Graduate School of Medicine, Nagoya 466-8550, Japan; Department of Urology Surgery, Affiliated Hospital of North Sichuan Medical College, Nanchong, China.

Cell reports
|February 16, 2024
PubMed
概括

免疫检查点抑制剂通过恢复耗尽的CD8+T细胞来提高抗瘤免疫力. 新的研究揭示了CXCL13驱动CD4+毛囊辅助T细胞透,增强癌细胞攻击和T细胞枯竭的洞察力.

关键词:
CP: 癌症 癌症 癌症在CXCL13中,CXCL13是最重要的.现场行动组-3在PD-1中使用PD-1.T细胞耗尽的情况在TCF1中,我们可以看到TCF1.癌症免疫学 癌症免疫学细胞毒性CD4 (((+) T细胞毛囊辅助T细胞是毛囊的辅助T细胞干状原始体的耗尽终端差异化的耗尽.

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