平均血小板体积和阻塞性睡眠呼吸暂停-呼吸暂停综合征之间的关联:系统性审查和元分析
Jun Zeng1,2,3, Jie He1,2,3, MeiFeng Chen1,2,3
1Clinical Medical College of Chengdu Medical College, Chengdu, Sichuan, China.
PloS one
|February 16, 2024
概括
平均血小板体积 (MPV) 在阻塞性睡眠呼吸暂停-呼吸暂停综合征 (OSAHS) 中升高,与疾病严重程度相关. 较高的MPV水平也可能表明OSAHS患者心血管疾病风险增加.
科学领域:
- 睡眠医学 睡眠医学
- 血液学 血液学 血液学
- 心血管疾病 心血管疾病
背景情况:
- 阻塞性睡眠呼吸暂停-呼吸暂停综合征 (OSAHS) 诊断依赖于多睡眠学 (PSG),这是一个复杂而昂贵的方法.
- 需要更简单,更实用,更具成本效益的生物标志物用于OSAHS诊断和严重程度评估.
- 平均血小板体积 (MPV) 正在作为OSAHS的潜在生物标志物进行研究.
研究的目的:
- 为了比较OSAHS患者和健康对照者之间的MPV值.
- 分析MPV和睡眠监测参数之间的关系.
- 在OSAHS中评估MPV与心血管疾病 (CVD) 风险的关联.
主要方法:
- 在主要医疗数据库中进行了系统的文献搜索,截至2023年8月2日.
- 对31篇选定文章的数据进行了元分析 (3604名OSAHS患者,1165名对照).
- 统计分析包括使用STATA和R的标准化平均差异 (SMD),相关系数和赔率比率 (OR).
主要成果:
- 与对照组相比,OSAHS患者的MPV显著升高 (SMD = 0.37,P < 0.001),特别是在严重的OSAHS患者中.
- 亚组分析证实在不同种族,BMI和研究设计的OSAHS中,MPV更高.
- 升高的MPV与睡眠参数相关,并与心血管疾病风险增加有关 (OR = 1.72,P = 0.022).
结论:
- MPV是评估OSAHS严重性的简单,具有成本效益和实用的指标.
- 在OSAHS患者中,MPV水平升高与患心血管疾病的风险增加有关.
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