生物分子凝结物的粘性弹性和流动激活能的决定因素
Ibraheem Alshareedah1, Anurag Singh1, Sean Yang2
1Department of Physics, University at Buffalo, Buffalo, NY 14260, USA.
Science advances
|February 16, 2024
概括
生物分子凝聚剂的动态取决于材料的特性. 网络放松是由相互作用和链条长度决定的,而流动激活能量仅取决于相互作用强度.
科学领域:
- 生物物理学的生物物理.
- 软物质物理学 软物质物理学
- 分子生物学分子生物学
背景情况:
- 生物分子凝聚物对于细胞组织和功能至关重要.
- 它们的物质特性,如粘性弹性,决定了它们的动态行为.
- 了解这些特性是理解细胞过程的关键.
研究的目的:
- 为了研究生物分子凝聚物的流体相动态的物理决定因素.
- 剖析分子相互作用和链条长度在凝结物质性质中的作用.
- 阐明控制网络放松和生物分子扩散的机制.
主要方法:
- 微观生物学技术与分子模拟的整合.
- 量化网络放松的时间尺度和能量.
- 分析具有不同参数的异型粘弹性凝缩物.
主要成果:
- 机械放松时间取决于分子间相互作用和链条长度.
- 流动激活能量独立于链条的长度,仅随相互作用强度而变化.
- 生物分子扩散受到粘性弹性和流动激活能量的结合的影响.
结论:
- 链长度和序列特定的多价值相互作用在凝结物特性中起着不同的作用.
- 这些发现提供了对生物分子凝结物的复杂材料和运输特征的洞察.
- 这项研究强调了分子架构和宏观材料行为之间的相互作用.
相关概念视频
Surface Tension, Capillary Action, and Viscosity
27.8K
Surface Tension
The various IMFs between identical molecules of a substance are examples of cohesive forces. The molecules within a liquid are surrounded by other molecules and are attracted equally in all directions by the cohesive forces within the liquid. However, the molecules on the surface of a liquid are attracted only by about one-half as many molecules. Because of the unbalanced molecular attractions on the surface molecules, liquids contract to form a shape that minimizes the number...
The various IMFs between identical molecules of a substance are examples of cohesive forces. The molecules within a liquid are surrounded by other molecules and are attracted equally in all directions by the cohesive forces within the liquid. However, the molecules on the surface of a liquid are attracted only by about one-half as many molecules. Because of the unbalanced molecular attractions on the surface molecules, liquids contract to form a shape that minimizes the number...
27.8K
Viscosity
5.9K
When water is poured into a glass, it falls freely and quickly, whereas if honey or maple syrup is poured over a pancake, it flows slowly and sticks to the surface of the container. This difference in the flow of different kinds of liquids arises due to the fluid friction between the liquid layers and the liquid and the surrounding material. This property of fluids is called fluid viscosity. In this example, water has a lower viscosity than honey and maple syrup.
The SI unit of viscosity is...
The SI unit of viscosity is...
5.9K
Bond Dissociation Energy and Activation Energy
8.9K
Bond energy is the energy required to break a bond homolytically. These values are usually expressed in units of kcal/mol or kJ/mol and are referred to as bond dissociation energies when given for specific bonds or average bond energies when indicated for a given type of bond over many compounds. Firstly, the bond dissociation energy for a single bond is weaker than that of a double bond, which in turn is weaker than that of a triple bond. Secondly, hydrogen forms relatively strong bonds with...
8.9K
Noncovalent Attractions in Biomolecules
50.7K
Noncovalent attractions are associations within and between molecules that influence the shape and structural stability of complexes. These interactions differ from covalent bonding in that they do not involve sharing of electrons.
Four types of noncovalent interactions are hydrogen bonds, van der Waals forces, ionic bonds, and hydrophobic interactions.
Hydrogen bonding results from the electrostatic attraction of a hydrogen atom covalently bonded to a strong-electronegative atom like oxygen,...
Four types of noncovalent interactions are hydrogen bonds, van der Waals forces, ionic bonds, and hydrophobic interactions.
Hydrogen bonding results from the electrostatic attraction of a hydrogen atom covalently bonded to a strong-electronegative atom like oxygen,...
50.7K
Arrhenius Plots
39.4K
The Arrhenius equation relates the activation energy and the rate constant, k, for chemical reactions. In the Arrhenius equation, k = Ae−Ea/RT, R is the ideal gas constant, which has a value of 8.314 J/mol·K, T is the temperature on the kelvin scale, Ea is the activation energy in J/mole, e is the constant 2.7183, and A is a constant called the frequency factor, which is related to the frequency of collisions and the orientation of the reacting molecules.
The Arrhenius equation can be used...
The Arrhenius equation can be used...
39.4K
Enzymes and Activation Energy
11.9K
The activation energy (or free energy of activation), abbreviated as Ea, is the small amount of energy input necessary for all chemical reactions to occur. During chemical reactions, certain chemical bonds break, and new ones form. For example, when a glucose molecule breaks down, bonds between the molecule's carbon atoms break. Since these are energy-storing bonds, they release energy when broken. However, the molecule must be somewhat contorted to get into a state that allows the bonds to...
11.9K


