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Updated: Jul 2, 2025

Genome-wide Analysis of HDAC Inhibitor-mediated Modulation of microRNAs and mRNAs in B Cells Induced to Undergo Class-switch DNA Recombination and Plasma Cell Differentiation
11:06

Genome-wide Analysis of HDAC Inhibitor-mediated Modulation of microRNAs and mRNAs in B Cells Induced to Undergo Class-switch DNA Recombination and Plasma Cell Differentiation

Published on: September 20, 2017

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让-7 miRNAs抑制HIC2以调节BCL11A转录和血红蛋白切换

Peng Huang1, Scott A Peslak2,3, Vanessa Shehu3

  • 1GMU-GIBH Joint School of Life Sciences, The Guangdong-Hong Kong-Macau Joint Laboratory for Cell Fate Regulation and Diseases, Department of Obstetrics and Gynecology, Guangdong Provincial Key Laboratory of Major Obstetric Diseases, Guangdong Provincial Clinical Research Center for Obstetrics and Gynecology, Guangdong-Hong Kong-Macao Greater Bay Area Higher Education Joint Laboratory of Maternal-Fetal Medicine, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou Municipal and Guangdong Provincial Key Laboratory of Protein Modification and Degradation, Guangzhou Medical University, Guangzhou, People's Republic of China.

Blood
|February 16, 2024
PubMed
概括

微RNAs (miRNAs) 通过控制HIC2表达来调节从胎儿血红蛋白 (HBG) 转换为成人血红蛋白 (HBB). Let-7 miRNA家族直接准HIC2,影响红状腺细胞中的HBG沉默.

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Describing a Transcription Factor Dependent Regulation of the MicroRNA Transcriptome07:23

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Published on: June 15, 2016

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