基于双纳体的双纳体免疫吸收剂用于高度选择性地消除瘤坏死因子-α
Jiewen Chen1, Guangshuai Yao1, Chundong Huang2
1MOE Key Laboratory of Bio-Intelligent Manufacturing, Liaoning Key Laboratory of Molecular Recognition and Imaging, School of Bioengineering, Dalian University of Technology, Dalian 116024, Liaoning, China.
ACS biomaterials science & engineering
|February 16, 2024
概括
这项研究开发了一种新型的免疫吸收剂,使用双原型纳米体有效地去除瘤缩因子-α (TNF-α). 新材料显示出高效率和安全性,为治疗自身免疫性疾病和败血症提供了潜力.
科学领域:
- 生物医学工程 生物医学工程
- 免疫学 免疫学 免疫学
- 材料科学 材料科学 材料科学
背景情况:
- 过度表达的瘤坏死因子-α (TNF-α) 与自身免疫性疾病和败血症有关.
- 目前的TNF-α吸附剂由于目标度低和疏水相互作用而面临限制.
研究的目的:
- 开发一种高亲和度的免疫吸收剂,以有效地去除TNF-α.
- 评估新型免疫吸收剂的疗效,容量和安全性.
主要方法:
- 构建针对两个不同的TNF-α位点的双重类纳米体 (NbC21).
- 将NbC21固定在吸收物质上.
- 使用兰迈尔异热法评估吸附能力.
- 评估动态TNF-α清除比率和血液相容性.
主要成果:
- NbC21对TNF-α具有很高的亲和力 (19.9 pM) .
- 理论上的最大吸附能力达到18.22 mg/g. 凝.
- 该NbC21-吸附剂在1:1000的吸附剂与血清比率下实现了~96%的杰出TNF-α清除比率.
- 观察到有利的血红相容性和长时间的储存稳定性.
结论:
- 双相纳米体免疫吸收剂显示出临床应用的巨大潜力.
- 开发的材料符合TNF-α去除的严格有效性和安全性标准.
- 这项技术为管理与TNF-α相关的炎症状况提供了有前途的方法.
更多相关视频
相关概念视频
Targeted Cancer Therapies
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...
There are several types of targeted therapies against specific...
Tumor Immunotherapy
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.


