肠道微生物群和食道癌症风险之间的因果关系:来自孟德尔随机化研究的证据
Kui Wang1,2, Jiawei Wang3, Yuhua Chen4
1Department of Gastroenterology, The First People’s Hospital of Yunnan Province, The Affiliated Hospital of Kunming University of Science and Technology, Kunming 650032, Yunnan, China.
Aging
|February 16, 2024
概括
这项研究研究了肠道微生物群.
科学领域:
- 微生物组研究的研究.
- 胃肠病学 胃肠病学
- 在瘤学瘤学.
背景情况:
- 肠道微生物群和食道癌 (EC) 之间的关系尚不清楚.
- 因果关系的含义需要进一步调查.
研究的目的:
- 评估肠道微生物群和食道癌 (EC) 之间的潜在因果关系.
- 识别与EC风险或保护相关的特定微生物种群.
主要方法:
- 利用了来自MiBioGen联盟 (18,340个样本) 的全基因组关联研究 (GWAS) 数据.
- 应用了两个样本的门德尔随机化 (MR) 与反向方差加权 (IVW) 分析.
- 进行了反向MR分析,以评估EC与微生物群之间的因果关系.
主要成果:
- 家庭Porphyromonadaceae和Candidatus Soleaferrea属显示出对EC的保护作用.
- 包括Catenibacterium,Eubacterium coprostanoligenes组,Marvinbryantia,Ruminococcaceae UCG010,Ruminococcus1和Sutterella在内的几种属与EC风险增加有关.
- 反向MR分析证实了EC与七种肠道微生物群类型之间的关联.
结论:
- 确定了特定的肠道微生物种群,它们对EC发育有保护性或有害作用.
- 这些发现可能会导致用于早期EC诊断的新生物标志物.
- 开发基于微生物群调节的食道癌向治疗干预措施的潜力.
相关概念视频
Cancer Prevention
6.2K
Several factors can increase the risk of cancer in an individual. About 50% of cancer cases can be prevented by adopting a healthy lifestyle, regular exercise, eating healthy, and following a modest cancer prevention diet. Epidemiological studies have consistently shown that populations with vegetable and fruit-rich diets have reduced the incidence of cancer. On the other hand, populations who have a diet rich in animal fat, red meat, junk food, or high calories are predisposed to cancer.
Some...
Some...
6.2K
Mismatch Repair
4.8K
Organisms are capable of detecting and fixing nucleotide mismatches that occur during DNA replication. This sophisticated process requires identifying the new strand and replacing the erroneous bases with correct nucleotides. Mismatch repair is coordinated by many proteins in both prokaryotes and eukaryotes.
The Mutator Protein Family Plays a Key Role in DNA Mismatch Repair
The human genome has more than 3 billion base pairs of DNA per cell. Prior to cell division, that vast amount of genetic...
The Mutator Protein Family Plays a Key Role in DNA Mismatch Repair
The human genome has more than 3 billion base pairs of DNA per cell. Prior to cell division, that vast amount of genetic...
4.8K
Anatomy of the Intestines
71.9K
Although digestion of proteins, carbohydrates, and lipids may begin in the stomach, it is completed in the intestine. The absorption of nutrients, water, and electrolytes from food and drink also occurs in the intestine. The intestines can be divided into two structurally distinct organs—the small and large intestines.
Small Intestines
The small intestine is an ~7 meter-long tube with an inner diameter of just 2.5 cm. Since most nutrients are absorbed here, the inner lining of the...
Small Intestines
The small intestine is an ~7 meter-long tube with an inner diameter of just 2.5 cm. Since most nutrients are absorbed here, the inner lining of the...
71.9K
Barrett Esophagus-I: Introduction
98
Barrett's esophagus is a medical condition where the esophageal mucosa is significantly damaged by stomach acid or other digestive fluids, often due to long-term exposure associated with gastroesophageal reflux disease (GERD). In GERD, a weakened or abnormally relaxed lower esophageal sphincter allows stomach acid to flow persistently into the esophagus.
This constant acid exposure transforms the esophagus's pink mucosal lining (stratified squamous epithelium) into a type of lining more...
This constant acid exposure transforms the esophagus's pink mucosal lining (stratified squamous epithelium) into a type of lining more...
98
What is Monogastric Digestion?
71.2K
The human body contains a monogastric digestive system. In a monogastric digestive system, the stomach only contains one chamber in which it digests food. Several other animal species also have monogastric digestive systems, including pigs, horses, dogs, and birds. This chapter, however, focuses on the human digestive system.
71.2K


