在对温度和离子强度变化的反应中触发刺激的多层膜用于受控的favipiravir药物释放
Li Xu1, Lang He1, Yinzhao Li1
1Institute of Life Sciences, Jiangsu University, Zhenjiang, Jiangsu 212013, People's Republic of China.
Biomedical materials (Bristol, England)
|February 16, 2024
概括
由块共聚合物微粒和生物聚合物制成的层叠层叠薄膜有效地加载和释放favipiravir. 这些温度敏感的膜为潜在的冠状病毒治疗提供了可控的药物输送.
科学领域:
- 材料科学 材料科学 材料科学
- 聚合物化学 聚合物化学
- 药物输送系统 药物输送系统
背景情况:
- 块共聚合物米塞尔和天然生物聚合物是用于先进应用的多功能材料.
- 层层组装 (LbL) 是制造功能薄膜的强大技术.
- 法维皮拉维尔是治疗冠状病毒感染的潜在抗病毒药物.
研究的目的:
- 开发新的LbL膜,以有效地加载和控制释放favipiravir.
- 为了研究这些用于药物输送的LbL膜的温度反应行为.
- 探索这些基于纳米粒子的LbL膜在按需药物释放方面的潜力.
主要方法:
- 使用块共聚合物微粒和天然生物聚合物之间的静电相互作用制造LbL薄膜.
- 膜结构,形态和胀/收缩行为对温度变化的反应的表征.
- 在不同温度和离子强度条件下评估法维皮拉维尔的负载能力和释放动力学.
主要成果:
- 在温度操纵时,LbL膜显示出稳定的结构和形态,具有可逆的膨胀/收缩行为.
- 药物释放速度因温度升高和离子强度增加而减缓,这是由于响应性构件的脱水造成的.
- 通过温度触发器实现了法维皮拉维尔脉冲释放,从而能够精确控制治疗剂的输送.
结论:
- 开发的基于纳米粒子的LbL膜为控制和按需*体外*药物释放提供了一个有前途的平台.
- 这些片段显示了针对冠状病毒治疗的抗病毒药物,如favipiravir的向输送的潜力.
- LbL膜的温度反应性允许精确调节药物释放动力学.
更多相关视频
08:39Magnetic and Thermal-sensitive PolyN-isopropylacrylamide-based Microgels for Magnetically Triggered Controlled Release
Published on: July 4, 2017
8.9K
10:07Preparation of Multifunctional Silk-Based Microcapsules Loaded with DNA Plasmids Encoding RNA Aptamers and Riboswitches
Published on: October 8, 2021
1.4K
相关概念视频
01:10In Vitro Drug Release Testing: Overview, Development and Validation
In vitro dissolution and drug release tests assess how quickly and how much of a drug is released from its dosage form into an aqueous medium under standardized laboratory conditions. These tests are essential tools in pharmaceutical development and quality assurance, offering insight into the drug's performance before clinical use.During formulation development, dissolution testing identifies incomplete or inconsistent drug release issues. It also supports decisions on selecting the optimal...
01:19Modified-Release Drug Delivery Systems: Rate-Programmed II
Rate-programmed drug delivery systems release drugs in a controlled manner to maintain therapeutic levels. Three main designs include reservoir, matrix, and hybrid systems.Reservoir systems consist of a drug core enclosed within a membrane that controls drug release. In non-swelling reservoir systems, polymers like ethyl cellulose or polymethacrylates are used. These do not hydrate in aqueous media and control release through membrane thickness, porosity, or insolubility. This type includes...
01:22Modified-Release Drug Delivery Systems: Drug Release Characteristics
Drug release from modified-release dosage forms is designed to achieve specific therapeutic effects by controlling the rate and extent of drug release. The classification of these drug release systems is based on key pharmacokinetic assumptions: drug disposition follows first-order kinetics, drug release is the rate-limiting step in absorption, and the released drug is rapidly and completely absorbed.There are four major models of drug release patterns. The first model is the slow zero-order...
01:23Modified-Release Drug Delivery Systems: Classification
Modified-release drug delivery systems improve drug efficacy and minimize side effects by controlling the rate and location of drug release. These systems fall into three categories: rate-programmed, stimuli-activated, and site-targeted.Rate-programmed systems release drugs at a predetermined rate, maintaining consistent therapeutic levels and reducing fluctuations that could lead to toxicity or subtherapeutic effects. These systems use polymeric matrices, reservoir-based designs, or osmotic...
01:22Modified-Release Drug Delivery Systems: Rate-Programmed I
Rate-programmed drug delivery systems (DDS) are designed to release drugs at specific, controlled rates to maintain consistent therapeutic levels. These systems are categorized based on their release mechanisms, including dissolution-controlled DDS, diffusion-controlled DDS, and combined dissolution-diffusion-controlled DDS.In dissolution-controlled DDS, the release rate depends on the slow dissolution of the drug itself or the surrounding matrix. Drugs with inherently slow dissolution rates,...
01:30Modified-Release Drug Delivery Systems: Stimuli-Activated
Stimuli-activated drug delivery systems are designed to release drugs in response to specific physical, chemical, or biological stimuli. These systems often utilize hydrogels—three-dimensional, hydrophilic polymer networks capable of swelling in aqueous environments and retaining significant fluid volumes. Upon exposure to particular stimuli, these hydrogels undergo structural transitions that allow the embedded drug to be released. Due to this adaptive behavior, such systems are also called...