通过气相化学功能反应改变的可生物降解聚合物表面的药物释放控制和抗炎作用
1Convergence Research Center for Treatment of Oral Soft Tissue Disease (MRC), Chosun University, 2 Chosundae 4-gil, Dong-gu, Gwangju 61452, Republic of Korea.
Biomedical materials (Bristol, England)
|February 16, 2024
概括
聚乳酸 (PLA) 的等离子体表面处理增强了普雷尼索隆的输送. 这种修改后的PLA显示了药物保留和延长释放的改善,为持续的抗炎作用提供了一种新方法.
科学领域:
- 材料科学 材料科学 材料科学
- 生物医学工程 生物医学工程
- 表面化学 表面化学
背景情况:
- 等离子体表面修饰是改变材料特性的一个关键技术.
- 聚乳酸 (PLA) 是一种广泛使用的可生物降解聚合物.
- 控制聚合物表面的药物输送对于治疗应用至关重要.
研究的目的:
- 为了研究从血表面修饰的聚乳酸 (PLA) 中控制的布雷迪诺的输送.
- 评估等离子治疗对PLA表面特征和药物释放动力学的影响.
- 评估体外生物反应,包括细胞行为和抗炎作用.
主要方法:
- 使用低压无线电频率等离子体与Ar,O2和CH4气体进行PLA表面修饰.
- 通过扫描电子显微镜,X射线光电子光谱 (XPS) 和接触角测量进行表征.
- 在体外的药物释放研究,细胞反应测定和细胞因子活性分析.
主要成果:
- 等离子处理创造了一个多孔的PLA表面结构,增加了粗度.
- 在XPS分析中,修改PLA的氧化碳含量更高.
- 普雷迪尼索隆的保持能力得到增强,导致药物释放时间延长.
- 细胞迁移和增殖得到改善,而炎症性细胞因子活性 (COX-2,TNF-α,IL-1β,IL-6) 减少.
结论:
- 对PLA的等离子体表面修饰有效地控制了普雷尼索隆的递送速度.
- 修改后的PLA表现出持续的抗炎药物释放特性.
- 这种方法为传统的药物输送方法提供了一个有希望的替代方案.
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