疼痛对化疗诱导的外周神经毒性症状负担的影响
Fawaz Mayez Mahfouz1, Tiffany Li1, Hannah C Timmins1
1Brain and Mind Centre, School of Medical Sciences, Faculty of Medicine and Health, The University of Sydney, Camperdown, Australia.
Journal of the National Comprehensive Cancer Network : JNCCN
|February 16, 2024
概括
痛苦的化疗诱导的外周神经毒性 (CIPN) 在癌症幸存者中显著加重症状负担. 识别痛苦的CIPN对于开发有针对性的治疗和康复策略至关重要.
科学领域:
- 在瘤学瘤学.
- 神经科学是一个神经科学.
- 患者报告的结果
背景情况:
- 化疗诱导的周围神经毒性 (CIPN) 影响癌症幸存者的生活质量.
- 疼痛对CIPN症状负担的具体影响还不清楚.
- 了解CIPN亚型对于有效管理至关重要.
研究的目的:
- 为了区分患有疼痛和无痛CIPN的患者的临床症状概况.
- 评估疼痛对CIPN患者整体症状负担的影响.
- 为癌症幸存者提供量身定制的治疗和康复方法.
主要方法:
- 对579名癌症幸存者的横截面研究,治疗后6个月.
- 使用患者报告结果,NCI-CTCAE和神经学检查评估CIPN严重程度.
- 参与者被分为疼痛CIPN (射击/烧伤疼痛) 和非疼痛CIPN (无射/烧伤疼痛的麻木/刺痛) 小组.
- 通过对睡眠,运动和寻求治疗的采访来评估行为变化.
主要成果:
- 24%的参与者患有疼痛性CIPN,48%患有非疼痛性CIPN,28%没有CIPN.
- 疼痛性CIPN患者在所有措施 (NCI-CTCAE,神经学分级,患者报告) 中表现出明显更高的CIPN严重程度.
- 痛苦的CIPN与对运动,睡眠障碍和寻求治疗行为增加的影响更大.
结论:
- 疼痛性CIPN与非疼痛性CIPN相比,与明显更高的症状严重程度和行为变化有关.
- 准确识别痛苦的CIPN子组是必要的,以改善患者的护理.
- 这项研究强调了对于患有痛苦CIPN的癌症幸存者需要专门干预的需要.
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