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Updated: Jul 2, 2025

Fibroblast Derived Human Engineered Connective Tissue for Screening Applications
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用3D重建的人体皮肤组织通过电穿孔转染纤维细胞

Géraldine Albérola1, Elisabeth Bellard1, Jelena Kolosnjaj-Tabi1

  • 1Institut de Pharmacologie et de Biologie Structurale (IPBS), Université de Toulouse, CNRS, Université Toulouse III - Paul Sabatier (UT3), Toulouse, France.

Bioelectrochemistry (Amsterdam, Netherlands)
|February 16, 2024
PubMed
概括

了解皮肤中的DNA电转移是DNA疫苗接种的关键. 我们的工程皮肤模型显示,DNA只能到达表面细胞,这可能是由于原基质限制了更深层的等离子体转移.

关键词:
原蛋白是一种原蛋白.电泳力是一种电泳力.电穿孔是一种电子穿孔.纤维母细胞细胞是如何形成的人类皮肤组织 皮肤组织转化 转化 转化 转化

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Introduction to Fibroblasts01:09

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Rudolph Virchow discovered spindle-shaped cells called fibroblasts in 1858. Inactive fibroblasts, called fibrocytes, become activated by various stimuli, such as growth factors and inflammatory cytokines. Activated fibroblasts play a crucial role in wound healing, inflammation, formation of new blood vessels, and cancer progression. Uncontrolled activation of fibroblasts results in fibrosis, the excess deposition of fibrous tissue, which can lead to scarring and affect normal organs. This...
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