人类的PRH1,PRH2易感性和耐药性以及Streptococcus mutans病毒性表型在病中指定了不同的微生物概况
Nongfei Sheng1, Lena Mårell1, Raviprakash Tumkur Sitaram1
1Department of Odontology/Cariology, Umeå University, 901 87, Umeå, Sweden.
EBioMedicine
|February 16, 2024
概括
主体遗传学和Streptococcus mutans粘附的毒性影响着脏病的发展. 根据宿主耐药性或易感性出现不同的微生物概况,影响菌菌群的组成和进展.
科学领域:
- 口腔微生物学 口腔微生物学
- 牙虫研究 牙虫研究
- 宿主-病原体相互作用
背景情况:
- 生活方式和糖糖驱动高病率人群中的多微生物转移.
- 在低患病率的环境中,宿主基因 (PRH1,PRH2) 和Streptococcus mutans粘附表型可能会影响的进展.
- 关于这些因素如何塑造脏病中的口腔微生物组的研究有限.
研究的目的:
- 为了研究宿主遗传表型 (PRH1,PRH2),Streptococcus mutans粘附毒性,以及发育中的开始性细菌之间的相互作用.
- 确定这些因素如何影响与病进展相关的微生物特征,在不同病发病率的青少年中.
- 分析S. mutans粘附表型的居住和感染概况及其对病的影响.
主要方法:
- 在452名瑞典青少年中分析了S. mutans附着素 (SpaP A/B/C,Cnm/Cbm) 现型,开始性链球菌和乳球菌.
- 根据高 (P4a),中度 (P6) 和低 (P1) 的PRH1,PRH2表型对参与者的分类.
- 在实验室和现场分析S. mutans分离物的粘合素表达,糖化和的活性机制.
主要成果:
- 在耐药 (P1) 宿主中,高毒性S. mutans是病进展所必需的.
- 在易受感染的宿主 (P4a,P6) 中,脏病涉及到更广泛的多微生物菌群,包括S. mutans和中度脏病原始体.
- 高毒性与不稳定的S. mutans居住和波动的粘附表达有关,而低/中等毒性与SpaP A表型显示稳定的居住.
结论:
- 宿主遗传敏感性/耐药性 (PRH1,PRH2) 和S. mutans附着的毒性表型决定了虫病中不同的口腔微生物特征.
- 这表明宿主基因与特定的细菌毒性因子之间存在复杂的相互作用,决定了的风险和呈现.
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