相关实验视频

Updated: Jul 2, 2025

Multiplexed Fluorescent Immunohistochemical Staining of Four Endometrial Immune Cell Types in Recurrent Miscarriage

Multiplexed Fluorescent Immunohistochemical Staining of Four Endometrial Immune Cell Types in Recurrent Miscarriage

Published on: August 4, 2021

尿路多环芳和来自病例控制研究的不明原因的复发性自发流产之间的关联

Chunxian Lv¹, Dandan Li², Zheng Zhang³

¹China CDC Key Laboratory of Environment and Population Health, National Institute of Environmental Health, Chinese Center for Disease Control and Prevention, Beijing 100021, China.

Ecotoxicology and environmental safety

|February 16, 2024

概括

暴露于3-甲 (3-BAA),一种单氧化多环芳 (OH-PAH) 的类型,与无法解释的复发性自发性流产 (URSA) 的风险增加有关. 需要进一步的研究来证实这些发现.

科学领域:

环境健康环境健康
生殖毒理学生殖毒理学
流行病学流行病学

背景情况:

多环芳 (PAH) 是环境污染物,与不良妊娠结果有关.
关于单次或混合PAH暴露对不明原因的复发性自发性流产 (URSA) 的特定影响的数据有限.
单氧化PAHs (OH-PAHs) 是PAHs的代谢物,它们在URSA中的作用需要研究.

研究的目的:

检查暴露于特定OH-PAHs与URSA风险之间的关联.
为了确定哪些OH-PAHs,单独或作为混合物,有助于URSA风险.
评估3-甲 (3-BAA) 作为URSA风险因素的潜力.

主要方法:

采用了一种病例控制研究设计.
在研究参与者中量化了16种OH-PAH.
统计分析包括后勤回归,加权量子总和 (WQS) 回归,贝叶斯核心机器回归 (BKMR) 和基于量子的g计算 (qgcomp).

主要成果:

在所有受试者中检测到1-纳夫托尔,2-纳夫托尔,9-和1-.
暴露于3-甲 (3-BAA) 的较高四分位数与URSA风险增加显著相关 (OR = 3.56).
多种混合物的分析始终确定3-BAA为OH-PAHs对URSA观察到的影响的主要贡献者.

结论:

暴露于3-甲 (3-BAA) 可能是导致不明原因的复发性自发性流产 (URSA) 的重要危险因素.
该研究强调了考虑特定OH-PAH代谢物的重要性,以了解环境暴露和生殖健康.
建议进行进一步的前性研究,以验证这些发现并阐明潜在的机制.

关键词:

案例控制研究研究.混合暴露分析混合暴露分析多环芳香碳化合物多环芳香碳化合物无法解释的复发性自发性流产

更多相关视频

Long-term Behavioral and Reproductive Consequences of Embryonic Exposure to Low-dose Toxicants

Long-term Behavioral and Reproductive Consequences of Embryonic Exposure to Low-dose Toxicants

Published on: March 6, 2018

Recurrent Escherichia coli Urinary Tract Infection Triggered by Gardnerella vaginalis Bladder Exposure in Mice

Recurrent Escherichia coli Urinary Tract Infection Triggered by Gardnerella vaginalis Bladder Exposure in Mice

Published on: December 4, 2020

相关概念视频

Cancer Prevention

Cancer Prevention

Several factors can increase the risk of cancer in an individual. About 50% of cancer cases can be prevented by adopting a healthy lifestyle, regular exercise, eating healthy, and following a modest cancer prevention diet. Epidemiological studies have consistently shown that populations with vegetable and fruit-rich diets have reduced the incidence of cancer. On the other hand, populations who have a diet rich in animal fat, red meat, junk food, or high calories are predisposed to cancer.
Some...

Teratogenicity

Teratogenicity

The ability of a drug to produce structural deformations and functional abnormalities in the developing embryo or the fetus is called teratogenicity, and the drug producing this effect is known as a teratogen. Teratogenic effects include stillbirth, miscarriage, intrauterine growth restriction, and neurocognitive delay. A teratogen may affect the embryo at different stages of development, which is important in determining the type and extent of the damage. During blastocyst formation, the early...

Mutagenicity and Carcinogenicity

Mutagenicity and Carcinogenicity

Mutagenicity and carcinogenicity refer to the ability of drugs to cause genetic defects and induce cancer, respectively. The International Agency for Research on Cancer (IARC) classifies agents into four groups based on their carcinogenic potential. Group 1 agents are known human carcinogens; group 2A agents are probably carcinogenic to humans; group 3 agents lack data to support their role in carcinogenesis; and group 4 includes agents for which data support that they are not likely to be...