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我们是否错过了与低分离乳腺辐射相关的急性毒性? 一份来自大型多中心队列研究的报告

Hassan Beydoun¹, Kent A Griffith², Reshma Jagsi³

¹Department of Radiation Oncology, Barbara Ann Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, Michigan.

International journal of radiation oncology, biology, physics

|February 16, 2024

概括

与4周的随访相比,对低分离全乳房辐射 (HF-WBI) 的2周随访没有增加急性毒性检测. 这一发现支持HF-WBI在早期乳腺癌患者的安全性和耐受性.

科学领域:

在瘤学瘤学.
辐射瘤学辐射瘤学
临床试验临床试验

背景情况:

低分离全乳房照射 (HF-WBI) 对乳腺癌有效,但关于急性毒性的数据有限.
之前的研究确立了长期的疗效和安全性,但不太关注治疗后的不良事件.

研究的目的:

为了确定治疗后2周的随访是否检测到HF-WBI患者的急性毒性,与4周的随访相比.
评估早期随访对在接受HF-WBI的乳腺癌患者中识别急性毒性的影响.

主要方法:

在HF-WBI患者的两个队列中,急性毒性的前性比较:4周的随访 (2013-2015年) 与2周的随访 (2016-2018年).
急性毒性定义为中度/严重的乳房疼痛和/或湿脱皮,从放射治疗结束前7天到结束后42天.
多变量分析根据患者年龄,BMI,吸烟状况和治疗技术进行调整 (IMRT与3D-CRT).

主要成果:

分析了2689名患者 (827名在4周队列中,1862名在2周队列中).
在未调整和调整的分析中,总体急性复合毒性在队列之间是相似的 (26.4%对27.7%).
毒性与患者因素和治疗技术有显著的关联,但不是随访计划.

结论:

较早的2周治疗后对HF-WBI的随访不会显著增加急性毒性的检测.
这项研究证实了HF-WBI的安全性和耐受性,为考虑这种乳腺癌治疗的临床医生和患者提供了有价值的数据.

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