一个关于西班牙药理学历史的帐户
Ana María Aldea-Perona1, Jesús Flórez Beledo2, Jesús Frías Iniesta3
1Hospital del Mar, Barcelona, Spain.
Pharmacological research
|February 16, 2024
概括
特奥菲洛·埃尔南多在西班牙开创了药理学,在马德里康普鲁登斯大学建立了实验和临床药理学. 他的门徒推进了这一领域,导致西班牙药理学会 (SEF) 和西班牙临床药理学会 (SEFC) 的成立.
科学领域:
- 药理学 药理学是指药理学的学科.
- 科学的历史科学的历史.
- 医学史 医学史 医学史
背景情况:
- 西班牙药理学的历史可以追溯到欧洲大学学位的建立,Teófilo Hernando在20世纪初成为一个关键人物.
- 赫尔南多受奥斯瓦尔德·施米德贝格博士后工作的影响,在马德里中央大学引入了实验药理学和临床治疗学,为西班牙现代药理学奠定了基础.
研究的目的:
- 提供西班牙药理学历史的叙述.
- 为了突出特奥菲洛·埃尔南多和他的门徒们的贡献.
- 概述西班牙临床前和临床药理学的发展,并确定关键研究领域.
主要方法:
- 西班牙药理学发展的历史回顾.
- 分析特奥菲洛·埃尔南多的先驱作用和学术贡献.
- 追溯赫尔南多及其学生培训的药理学家的血统.
- 记录制药学会的建立和研究贡献.
主要成果:
- 特奥菲洛·埃尔南多在西班牙建立了实验和临床药理学,培养了一代药理学家.
- 西班牙内战和第二次世界大战中断了临床前和临床药理学的划分,在20世纪80年代部分发展.
- 西班牙药理学会 (SEF) 成立于1972年,随后在20世纪90年代成立了西班牙临床药理学会 (SEFC).
- 西班牙药理学家在神经心理药理学,心血管药理学和其他领域做出了重大贡献,例如光滑肌肉,胃肠病学,药物遗传学和肝毒性.
结论:
- 特奥菲洛·埃尔南多是建立药理学作为西班牙现代科学的一个关键人物.
- 尽管有历史上的挑战,西班牙药理学已经发展得很大,在各种专业领域作出了显著的贡献.
- 预计西班牙将进一步发展临床前和临床药理学.
相关概念视频
Drug Regulation
1.4K
Drug regulation encompasses the management of drug usage by evaluating its safety and efficacy through assessments conducted by regulatory authorities. Regrettably, the history of drug regulation is marred by several catastrophic events. One such incident is the Elixir Sulfanilamide tragedy, in which the toxic compound diethyl glycol was included in a sweet-tasting medication, leading to numerous fatalities. This event prompted the enactment of the Food, Drug, and Cosmetic Act in 1938. Under...
1.4K
Pharmacovigilance
833
Post-marketing surveillance is a critical component of pharmaceutical regulation, often uncovering unanticipated adverse drug reactions (ADRs) once a drug is widely used over an extended period.
This process, termed pharmacovigilance, aims to detect, evaluate, and minimize harmful effects related to medication use. The data collection for pharmacovigilance depends on spontaneous reporting systems, where healthcare professionals or patients voluntarily report suspected ADRs.
In some cases, there...
This process, termed pharmacovigilance, aims to detect, evaluate, and minimize harmful effects related to medication use. The data collection for pharmacovigilance depends on spontaneous reporting systems, where healthcare professionals or patients voluntarily report suspected ADRs.
In some cases, there...
833
Pharmacodynamics: Overview and Principles
1.1K
Pharmacodynamics is a scientific field that delves into drugs' intricate biochemical, cellular, and physiological effects on the human body. The study of pharmacodynamics helps us understand how drugs interact with the body and elicit various responses.
Most drugs' effects result from their interactions with drug receptors or targets within the body. These interactions trigger specific responses at the cellular or systemic level. Drug receptors can be found on the surfaces of cells or...
Most drugs' effects result from their interactions with drug receptors or targets within the body. These interactions trigger specific responses at the cellular or systemic level. Drug receptors can be found on the surfaces of cells or...
1.1K
Preclinical Development: Overview
4.4K
Preclinical development consists of a series of tests that ensure the safety and efficacy of a new therapeutic compound before it is tested in humans. There are four main phases to this process. First, safety pharmacology tests are conducted to ensure the drug does not produce any acutely harmful effects. These tests examine parameters such as bronchoconstriction, cardiac dysrhythmias, blood pressure changes, and ataxia. Next, preliminary toxicological testing is performed to determine the...
4.4K
Drug Administration and Therapy Phases: Overview
465
Drugs, the chemical agents used in diagnosing, treating, or preventing diseases, undergo a four-phase process of development: pharmaceutic, pharmacokinetics, pharmacodynamics, and therapeutic.
The pharmaceutical phase focuses on leveraging the physicochemical properties of the drug to design and manufacture an effective product. Variants include orally administered tablets or capsules, topical creams or ointments, and parenteral-delivery solutions or emulsions.
The pharmacokinetic phase...
The pharmaceutical phase focuses on leveraging the physicochemical properties of the drug to design and manufacture an effective product. Variants include orally administered tablets or capsules, topical creams or ointments, and parenteral-delivery solutions or emulsions.
The pharmacokinetic phase...
465
Drug Discovery: Overview
7.9K
Drug discovery is a multifaceted process involving extensive screening, testing, and optimization of lead compounds to identify potential new drugs for therapeutic use. It combines several approaches, including screening large numbers of natural products, chemical modification of known active molecules, identification of new drug targets, and rational design based on biological mechanisms and drug-receptor structure. These approaches are carried out in both academic research laboratories and...
7.9K


